Oxford Biotrans
Developing a scalable process for proprietary enzyme production
Taking Oxford Biotrans’ technology from innovation to commercialisation
UK based SME Oxford Biotrans utilised CPI’s expertise as it progressed its technology from innovation to commercialisation.
Oxford Biotrans is a University of Oxford spin out company, supported by over 20 years of scientific expertise and research. The company is working to develop and commercialise enzymatic process technologies that yield high value chemical compounds.
Oxford Biotrans worked with CPI to develop a scalable process for production of its proprietary enzyme.
![](https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/oxford-grapefruit.jpg?w=1920&h=1080&q=60&fm=jpg&fit=crop&dm=1559212133&s=7974481932153bad8e93aa64dcc0db82 1920w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/oxford-grapefruit.jpg?w=1120&h=630&q=60&fm=jpg&fit=crop&dm=1559212133&s=4922c264488ee34bafbf28ea77a82e2c 1120w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/oxford-grapefruit.jpg?w=800&h=450&q=60&fm=jpg&fit=crop&dm=1559212133&s=eae2051c6f5a1b8406864c9578e88f09 800w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/oxford-grapefruit.jpg?w=1600&h=900&q=45&fm=jpg&fit=crop&dm=1559212133&s=9f7570de16942b6907fdb8870000b34a 1600w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/oxford-grapefruit.jpg?w=480&h=270&q=60&fm=jpg&fit=crop&dm=1559212133&s=8fdfe1ff4f463ee165f5d9fbb71de4e0 480w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/oxford-grapefruit.jpg?w=960&h=540&q=45&fm=jpg&fit=crop&dm=1559212133&s=8d2cef1ab11f824b7142a5b5e81d8fe0 960w)
“ Our project with CPI was the springboard for our technology commercialisation programme and subsequent market launch. The CPI team were knowledgeable, approachable and responsive and proved invaluable in rapidly overcoming the complex challenges that developing any new process requires. ”
![Jason King Jason King](https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Jason-King.jpg?w=100&h=100&q=60&fm=jpg&fit=crop&dm=1632736046&s=b6fe48e6ea33eddc9b54e6e644463ea0)
Achievements
Inputs
- Facilities
- R&D&I
- Technical knowledge and expertise
- Process validation
Outputs
- Development milestone achieved
- New fermentation process developed
- Economic business case refined
Outcomes
- New product to market
- £4.6m private sector investment secured
- Jobs created and safeguarded
![](https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/ibb.jpg?w=1920&h=1080&q=60&fm=jpg&fit=crop&dm=1559212688&s=0276dc40c8a819ac58721e1d27c08437 1920w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/ibb.jpg?w=1120&h=630&q=60&fm=jpg&fit=crop&dm=1559212688&s=1ea5123452c2a69548a65bc60063b92c 1120w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/ibb.jpg?w=800&h=450&q=60&fm=jpg&fit=crop&dm=1559212688&s=7cdf2906257f3b394ef1544cb7ddd1be 800w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/ibb.jpg?w=1600&h=900&q=45&fm=jpg&fit=crop&dm=1559212688&s=37fa148e5a7c384778496dda8437729b 1600w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/ibb.jpg?w=480&h=270&q=60&fm=jpg&fit=crop&dm=1559212688&s=eabfac613f9fe5e3fc35140d539d31d8 480w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/ibb.jpg?w=960&h=540&q=45&fm=jpg&fit=crop&dm=1559212688&s=6f20a8b14c862e912e387a129f56a510 960w)
The challenge
Oxford Biotrans Limited, a University of Oxford spin-out company formed in 2013, approached CPI for support in the development of a scalable fermentation process to produce its proprietary enzymes.
The company has developed a unique process for the production of nootkatone, the flavour and scent of grapefruit, from valencene, a citrus extract readily obtained from oranges. Since this process is catalysed by an enzyme, the nootkatone is designated a natural product. Nootkatone is used in food, beverage, cosmetic and personal care products.
Economic and environmental advantages of the technology include: (i) the ability to offer security of supply of natural-labelled nootkatone; (ii) low energy-intensity and limited waste and; (iii) production cost advantages, derived from the high selectivity and activity of the proprietary enzyme. The company is working on the production of other products using further enzymes from its patented library.
To unlock these benefits, it was vital to have a scalable fermentation process to produce the enzymes. As Oxford Biotrans was a young, virtual company, it sought to collaborate with an open access research organisation to perform the process development. However, maintaining IP ownership position was of paramount importance and key to protecting the interests of the company’s investors.
How CPI helped
Oxford Biotrans initially approached CPI in 2013 to undertake its development project.
Reassured by CPI’s experienced team and open access approach, in addition to the ability to retain full ownership of the IP, the project was awarded, and process development activities began at CPI’s National Industrial Biotechnology and Biorefining Facility.
CPI worked closely with Oxford Biotrans throughout the project, allowing them to gain in-depth technical knowledge of the process. This knowledge was used to update the company’s techno-economic business case which in turn validated the commercial viability of the nootkatone process for the Oxford Biotrans investors.
As the project concluded, Oxford Biotrans’ enzyme production process had moved from the innovation stage of its development through to a stage in which it was seen as scalable and ready to be transferred into a contract manufacturing facility.
With an initial backing of £0.7m, it was vital to deliver a scalable process within a compressed timeline. Oxford Biotrans reached this important investment milestone in under 2 years, by achieving a manufacturing process capable of producing commercial amounts of material. In turn, a further £4.6m of investment has been secured since 2015, allowing the company to grow headcount to 12 and enabling further RD&I activities on additional products within their portfolio.
For a spin-out company with minimal manufacturing assets, the road to commercialisation often presents significant challenges. However, access to expertise and open access facilities at CPI allowed Oxford Biotrans to take their economically and environmentally superior process from innovation to commercial manufacture faster, and with a significantly reduced level of risk.
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