Growing the potential for agritech innovation
The agritech market is constantly striving to develop biological solution for agricultural materials. CPI understand the challenges relating to the development of biologically based agricultural materials such as the efficiency of the process, the shelf life of the product, the formulation of the finished product and the potential inefficiency of the biological once applied in the field. Further challenges relating to the technological development of nucleic acids or proteins which require a deeper understanding of molecular stability or protein engineering.
The current agricultural products used on the field of many farms contain large quantities of chemicals which are often harmful to the waterways and other plants within the fields. With the advancements enabled by the biotechnological expertise and knowledge at CPI, we can assist in the replacement of these with a biological alternative creating a more positive impact upon the environment whilst keeping the required level of active.
What are the solutions?
Every global challenge has a solution whether it be improving bioprocesses, improving formulation or the development of strains and molecular based technology. At CPI, we aim to overcome these market challenges using our world-leading facilities and expertise to assist companies in their development towards the required solution.
The improvement of bioprocesses can aid those in the agritech market to reduce the production costs by increasing the cell titres and viability in order to be commercially more competitive with their chemical counterparts.
Improving the formulation and encapsulation of the biological active can lead to an increased product life giving the ability to reduce waste. The improvement of the final product formulation can also increase the levels of efficiency and ease of application meaning that the product can be used in smaller doses and simply applied to the areas of the field necessary. Both the reduction of waste and the increasing level of efficiency can lead to a reduction of cost for those working in agriculture.
CPI’s ability to develop microbial strains and molecular based technologies can aid our customers to overcome the challenges relating to the development of nucleic acids and proteins. The capability of CPI to develop strains inhouse as well as the ability to work on the scale up of the bioprocesses and the ability to analyse and optimise the final formulation give us a solid grounding in the overall processes of the agritech market.
How we can help you?
We have the experience, extensive knowledge and capabilities for:
- Handling different microbial strains across our teams of microbiologists, strain development, fermentation, downstream processing and analytical scientists.
- Strain development, process development and optimisation at laboratory scale.
- Anaerobic and aerobic fermentation capability
What makes us unique
- Selection of glass and stainless-steel fermenters from 250ml through to a 10,000L demonstration scale facility
- Strong collaboration with CPI Formulation to enable a full agritech development package from strain development through production and formulation
- Suite of analysis methods on-line, at-line and high-throughput
- Upstream and Downstream biological process development and optimisation
- Experience in the encapsulation, reformulation and dedusting of microbial products
- Development and production of sensors which have agricultural applications
Microbial Strain Development
At CPI we have vast experience in the handling of different microbial strains across our teams of microbiologist and strain development function. This experience covers the identification, isolation, growth and characterisation of microbial strains. The team here at CPI can assist in the identification of the optimal microbe that will meet expectations to enable the production of the desired end product.
If a customer already has a collection of cultures we have a variety of pieces of equipment that would enable us to isolate the required strain utilising the experience of the microbial science team accompanied by the expertise of the genetically modified micro-organisms team.
The growth of microbes for the creation of cell banks and preliminary process testing utilising the bench scale systems including shake flasks and high-throughput system located at CPI facilities. These microbes can then be taken and screened to ensure requirements of the customer and projects are met at this stage.
The team at CPI have proven experience and expertise in the development and optimisation of bioprocesses for the production of microbial biomass for use in biological agritech sector. This optimisation covers the media involved in the process, the process itself and moving into the scale-up of the fermentation.
We have the ability to identify the most appropriate media used for the initial validation of processes which can then be optimised via media development to increase the levels of efficiency and ensure the maximisation of yield and profit.
Bioprocess Scale Up
We have a dedicated scale up team with extensive experience in demonstrating lab-based processes in pilot and demonstration scale facilities. Sitting alongside the dedicated scale up team is a technology transfer team to assist with the documentation relating to all safety, manufacturing and quality for the scale up of processes.
The world-leading facilities at CPI include stainless steel safety-engineered fermentation facilities with working volumes up to 10,000L and process engineering capability to design, install and operate large scale fermenters.
CPI have the capability to take fermentation and bioprocessing processes from bench/small scale to demonstration scale ready for commercial adoption.
CPI formulation have extensive experience across a number of markets that can be applied to the agritech market. The process of formulation cover design, testing, optimisation, purification and scale-up. We have experience and relevant facilities to assist in the design of the formulation including screening to find components and characterisation of class 1 microorganisms. The formulation created in the design process can then be tested using high-throughput screening to analyse the stability of the formulated product and the stability of the active microbial component.
Optimisation of the formulation includes the encapsulation of active to ensure the correct dispersion in location, the reformulation of the active and the dedusting of the microbial product in our powders laboratory. This optimised formulation is then purified through filtration or centrifugation and drying through freeze or spray drying.