Controlling Crystallisation
Fine tuning crystallisation process parameters in real time
Obtaining real-time process data using an in-line microscope and particle sizer
Crystallisation reactions critically depend on the temperature profile. CPI used an in-line microscope and an in-line particle sizer to track this reaction in real-time, recording crystal properties as a function of temperature.
The trials confirmed that the combination of a precise crystal size measurement and visual inspection enables fine-tuning of the process parameters and crystals of the desired size.
This approach can be extended to other process analytical technologies, such as in-line Raman spectroscopy, to follow chemical reactions in real-time. This provides increased understanding and subsequent control of the process, reducing processing time and saving resources.
Achievements
Inputs
- Radley’s reactors
- In-line particle sizer (focussed beam reflectance measurement)
- In-line microscope
Outputs
- Particle size distributions for crystallisation
- Real-time microscopic images during crystallisation
Outcomes
- Increased understanding of dynamics of crystallisation
- Showcased the potential of using process analytical technology for crystallisations and other processes
