Fine tuning crystallisation process parameters in real time
Obtaining real-time process data using an in-line microscope and particle sizer
Crystallisation reactions critically depend on the temperature profile. CPI used an in-line microscope and an in-line particle sizer to track this reaction in real-time, recording crystal properties as a function of temperature.
The trials confirmed that the combination of a precise crystal size measurement and visual inspection enables fine-tuning of the process parameters and crystals of the desired size.
This approach can be extended to other process analytical technologies, such as in-line Raman spectroscopy, to follow chemical reactions in real-time. This provides increased understanding and subsequent control of the process, reducing processing time and saving resources.
An input is a unique capability, service or method of support that was provided, such as equipment or expertise.
- Radley’s reactors
- In-line particle sizer (focussed beam reflectance measurement)
- In-line microscope
An output is the result of the work, such as an experimental finding, an actual product or a pilot demonstrator.
- Particle size distributions for crystallisation
- Real-time microscopic images during crystallisation
An outcome arises from implementing the outputs, for example, a profit, an investment, providing jobs or delivering societal benefits. Outcomes continue once an innovation has been implemented and deliver benefit every year.
- Increased understanding of dynamics of crystallisation
- Showcased the potential of using process analytical technology for crystallisations and other processes