Smarter, faster and more sustainable biologics manufacturing
Intensified upstream and downstream processes tailored to your biologics pipeline
Biopharmaceutical developers increasingly need faster, more efficient and lower-impact production. In modern bioprocessing, process intensification helps meet this demand across multiple modalities. Antibodies, as the largest biologics class with well-defined behaviour, are particularly well suited to advanced control, perfusion and continuous purification. These approaches increase productivity in scaling next-generation biologics.
Accelerate development through automation
High-throughput and automated workflows reduce optimisation time and improve scale readiness.
Strengthen manufacturing resilience
Smaller footprints and flexible equipment reduce dependency on large fixed assets and ease supply-chain pressures.
Improve sustainability
Lower media, buffer, resin and energy use supports ESG goals and delivers meaningful cost efficiencies.
Reduce risk, increase confidence
Generate real industrial data to support investment decisions, future facility design and tech adoption.
End-to-end intensified bioprocessing, powered by real data
CPI’s intensified platforms incorporate:
- High-throughput perfusion development with automated control of pH, dissolved oxygen, agitation and temperature across 24-vessel design spaces.
- Advanced process control and cloud-based data architectures to support predictive, model-driven operation.
- Multi-column chromatography to reduce resin consumption, enable smaller column formats and decrease overall footprint and cost.
- Single-pass tangential flow filtration and in-line buffer exchange to streamline downstream processing and simplify final formulation.
Discover what’s possible
Book a virtual tour of CPI’s National Biologics Manufacturing Centre to see our state-of-the-art equipment in action, including the Ambr® 250 Perfusion system and cutting-edge digital simulation and modelling tools.
Complete the form below to book.
Capabilities that accelerate process intensification
CPI supports organisations from early feasibility studies through to production-relevant demonstrations, helping them understand the practical implications of process intensification and build confidence in scale up and technology adoption.
CPI’s integrated offer also brings together:
- Continuous downstream processing.
- Real-time analytics and advanced control.
- Techno-economic and life cycle assessments.
- Predictive, model-driven performance insights.
These combined capabilities show how intensification performs in practice, not just in theory, and help identify the conditions that deliver the greatest efficiency gains.
Discover our track record of innovation
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A staged pathway to process intensification
1. Feasibility Sprint (1 month)
Using your existing data to build a bioprocess model that assesses suitability for intensification and identifies the most impactful process improvement opportunities.
2. Experimental proof of concept (2 months)
Small-scale perfusion trials to confirm upstream performance and define the design space, supported by bioprocess modelling to predict large-scale outcomes and enable a clear go/no-go decision.
3. Advanced Development to pilot scale demonstration
A tailored programme to optimise, scale, and pilot your process, from high-throughput perfusion optimisation to end-to-end continuous biomanufacturing, supported by modelling, LCA, and TEA to predict full-scale manufacturing performance.
Find out more about the staged pathway and start your intensification journey today.
Built for antibodies and beyond
CPI supports a broad range of biologics, including:
- Monoclonal antibodies (mAbs)
- Recombinant proteins and enzymes
- Viral vectors
- Next-generation cell and gene therapy components
Our industrial test beds allow extended continuous runs, integrated PAT, and advanced process control — enabling safe, data-led decision-making for future manufacturing strategies.
Your partner in sustainable, scalable bioprocessing
As a translational innovation organisation with deep biologics expertise, CPI provides:
- Industrial-grade test beds for continuous bioprocessing.
- Multidisciplinary teams across biologics, automation, digital and sustainability.
- Data-driven sustainability assessments (TEA and LCA).
- Proven experience supporting UK and international innovators.
Unlock higher yields, lower costs and greater resilience through smarter, more sustainable biomanufacturing. Book your free workshop or speak to one of our experts.
Will process intensification work for you?
Join CPI’s biologics experts for a free, one-hour diagnostic workshop designed to help you unpack the challenges holding back your upstream or downstream performance. In this focused session, we will explore where productivity losses, scale constraints, or cost pressures are emerging in your process, and discuss how process intensification could help you overcome them. You will leave with clear next steps, practical insight, and a better understanding of whether intensification could deliver meaningful improvements for your organisation. Contact Asif Tulah at CPI to arrange.
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Let’s innovate together
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