Biostreamline event showcases project results
28 Jun 2019
An innovative collaboration to streamline the development of cost-effective next generation biotherapeutics hosted a dissemination event at CPI Darlington on the 26th June to showcase the project results.
BioStreamline is a highly innovative, collaborative project involving six partners across the UK including Lonza Biologics, UCB Celltech, Sphere Fluidics, Horizon Discovery, Alcyomics Ltd and CPI. This £11.2m project, applies cutting-edge technologies to overcome some of the most significant shortcomings of the biologics supply chain and deliver cost-effective therapies to patients.
BioStreamline, with a focus on monoclonal antibody therapeutics, aims to overcome such challenges by applying new technologies that will make it easier to identify failing drugs earlier in development, as well as improving development and manufacturing processes.
The project involved the following major areas:
- Development of a new single cell analysis system (Cyto-Mine®) and associated methodologies to enable screening of B‑cells for antibody discovery and analysis of antibody-producing clones for selection of high-producing cell lines. Delivery of this system will increase the speed and efficiency of the entry into the biologics supply chain.
- New approaches to cell line development using genome-wide gene knock-out screening using CRISPR-Cas9 to improve specific cell line features including increased productivity.
- Creation of an agile, flexible and improved approach to biotherapeutics developability. Following expression and purification of 50+ mAbs using industry leading platforms, data on the biochemical, biophysical and stability of each molecule was collected and together with other inputs lead to the design of a developability tool which will enable more accurate decision making.
- Investigation of clinically informative, easy to implement, preclinical assessment of immunogenicity risks of biotherapeutics to minimise exposure of human patients to potential safety risks during early clinical trial development.
By gaining a better understanding of candidate molecules earlier in the process, manufacturers will be able to make more informed decisions, reducing drug development risk and provide more efficient use of time and resources.
The collaboration partners presented a series of talks showcasing the results achieved through the course of this major project.
![Frank Miller, CPI Frank Miller, CPI](https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Frank-Miller-at-BioStreamline.jpg?w=1920&h=1080&q=60&fm=jpg&fit=crop&dm=1561726542&s=685bcdf5a73ef36717168fca2e6bc5a7 1920w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Frank-Miller-at-BioStreamline.jpg?w=1120&h=630&q=60&fm=jpg&fit=crop&dm=1561726542&s=a1de6527cd8dec4b3fc13fc9f8215dc6 1120w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Frank-Miller-at-BioStreamline.jpg?w=2240&h=1260&q=45&fm=jpg&fit=crop&dm=1561726542&s=a74d13a9f9e54326477c4b41da048af5 2240w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Frank-Miller-at-BioStreamline.jpg?w=800&h=450&q=60&fm=jpg&fit=crop&dm=1561726542&s=b31119faa78c1106d2aff78e0a5355a6 800w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Frank-Miller-at-BioStreamline.jpg?w=1600&h=900&q=45&fm=jpg&fit=crop&dm=1561726542&s=29630716333c074c075839fae75cb2ed 1600w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Frank-Miller-at-BioStreamline.jpg?w=480&h=270&q=60&fm=jpg&fit=crop&dm=1561726542&s=2b7191948f6db597f09b0a1c23ce2aaf 480w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Frank-Miller-at-BioStreamline.jpg?w=960&h=540&q=45&fm=jpg&fit=crop&dm=1561726542&s=94248de6e88ad018bcf36babb62a726f 960w)
![Mark Bustard, CPI Mark Bustard, CPI](https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Markk-Bustard-Biostreamline.jpg?w=1920&h=1080&q=60&fm=jpg&fit=crop&dm=1561726570&s=e1cf9d412169d4a2e448b6b4dc6f83d5 1920w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Markk-Bustard-Biostreamline.jpg?w=1120&h=630&q=60&fm=jpg&fit=crop&dm=1561726570&s=483b94bfab7c95dac5d8424a854e9456 1120w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Markk-Bustard-Biostreamline.jpg?w=2240&h=1260&q=45&fm=jpg&fit=crop&dm=1561726570&s=73635eb5fee93a9b43369363663f62d4 2240w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Markk-Bustard-Biostreamline.jpg?w=800&h=450&q=60&fm=jpg&fit=crop&dm=1561726570&s=a875d5e18d4bae0db658f9115e38b349 800w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Markk-Bustard-Biostreamline.jpg?w=1600&h=900&q=45&fm=jpg&fit=crop&dm=1561726570&s=90511397ddf5e873fe270ff7c6bd799e 1600w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Markk-Bustard-Biostreamline.jpg?w=480&h=270&q=60&fm=jpg&fit=crop&dm=1561726570&s=1b1b2a03e52e9dd5c7e8106dd6ccb716 480w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/Markk-Bustard-Biostreamline.jpg?w=960&h=540&q=45&fm=jpg&fit=crop&dm=1561726570&s=3763e2a6c9d76494796d3058e62eb382 960w)
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![Vicky Smith, CPI Vicky Smith, CPI](https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/female-speaker-at-biostreamine.jpg?w=1920&h=1080&q=60&fm=jpg&fit=crop&dm=1561726282&s=f058be6eb59be66a0b92bc56f0ead4fe 1920w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/female-speaker-at-biostreamine.jpg?w=1120&h=630&q=60&fm=jpg&fit=crop&dm=1561726282&s=922e1cfd772018aa173ccce9a1bf4a4a 1120w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/female-speaker-at-biostreamine.jpg?w=2240&h=1260&q=45&fm=jpg&fit=crop&dm=1561726282&s=654d77c25a5581d559fef7cfb7982fef 2240w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/female-speaker-at-biostreamine.jpg?w=800&h=450&q=60&fm=jpg&fit=crop&dm=1561726282&s=9322e994d5e2080f1dc9b6f5f4f3d0b9 800w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/female-speaker-at-biostreamine.jpg?w=1600&h=900&q=45&fm=jpg&fit=crop&dm=1561726282&s=ebbe9342a8568a09a9385560a3ed3a05 1600w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/female-speaker-at-biostreamine.jpg?w=480&h=270&q=60&fm=jpg&fit=crop&dm=1561726282&s=328db1e823514ac1e9fd844440ae3bc1 480w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/female-speaker-at-biostreamine.jpg?w=960&h=540&q=45&fm=jpg&fit=crop&dm=1561726282&s=5a8bb06e768b86644b1cc19a9504106e 960w)
![Uwe Gottschalk, CPI Uwe Gottschalk, CPI](https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/female-speaker-in-grey-suit-at-biostreamine.jpg?w=1920&h=1080&q=60&fm=jpg&fit=crop&dm=1561726265&s=2f00fb6b0350d3e7859f77154eb2706a 1920w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/female-speaker-in-grey-suit-at-biostreamine.jpg?w=1120&h=630&q=60&fm=jpg&fit=crop&dm=1561726265&s=a022069feb85dc9e4b8d2137df12efa4 1120w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/female-speaker-in-grey-suit-at-biostreamine.jpg?w=2240&h=1260&q=45&fm=jpg&fit=crop&dm=1561726265&s=65c439fa04becbbe83d5f3e5b8449995 2240w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/female-speaker-in-grey-suit-at-biostreamine.jpg?w=800&h=450&q=60&fm=jpg&fit=crop&dm=1561726265&s=3aab245147ad19f62be14afe952dbfa2 800w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/female-speaker-in-grey-suit-at-biostreamine.jpg?w=1600&h=900&q=45&fm=jpg&fit=crop&dm=1561726265&s=7d472d51a7b8d6bf5fd4479ff59b4df4 1600w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/female-speaker-in-grey-suit-at-biostreamine.jpg?w=480&h=270&q=60&fm=jpg&fit=crop&dm=1561726265&s=5bd491c884bbca61ba7ef76d6756358f 480w, https://optimise2.assets-servd.host/smart-hoopoe/production/content/images/female-speaker-in-grey-suit-at-biostreamine.jpg?w=960&h=540&q=45&fm=jpg&fit=crop&dm=1561726265&s=885e9c4dadc749809b1b576c91fd19af 960w)
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