IUK Scalable Medicines Manufacturing Project Showcase
Event Details
Join us for this live showcase of a novel proof-of-concept platform for continuous and automated downstream process development, developed through a £422k Innovate UK-funded collaboration led by Causeway Sensors in partnership with CPI and Industrial Systems and Control Ltd (ISC).
Downstream purification remains a bottleneck in intensified monoclonal antibody manufacture, constrained by the limited scalability of development workflows to industrial production scale. This project aims to address this challenge by combining in-line Process Analytical Technology (PAT) and closed-loop process control to enable continuous optimisation of biotherapeutic yield and purity in real-time.
Building on CPI’s end-to-end continuous biomanufacturing platform, the consortium has focused on the holistic optimisation of key polishing unit operations in downstream processing. Fully automated adjustment of process conditions is enabled via real-time analysis of critical quality attributes, integrated into the unit operation process via:
- Advanced model-based process control algorithms developed by ISC to enable real-time adjustment;
- Discrete in-line integration of the Causeway Sensor’s TITAN platform: a dual-channel chip-based biosensor platform for duplexed antibody titre and purity measurement.
This cross-partner event will share the technically ambitious outcomes of the project, which demonstrate an alternative to traditional early-stage development workflows that supports high-density experimentation in a manufacturing-relevant format, offering a more sustainable, resource-efficient approach to downstream bioprocessing.
The showcase will be of particular interest to industry professionals and academic researchers working in downstream process development, automation, PAT strategy, CMC, digital biomanufacturing and advanced control. It offers a unique opportunity to explore how emerging technologies are capable of solving long-standing industrial challenges, and to engage directly with the innovators behind the platform.
Event highlights:
Live system demonstration and tour of CPI’s downstream processing facilities
Spotlight presentations from each consortium partner on technical innovations
Lunch, refreshments and opportunities for discussion and collaboration