mRNA therapeutics

Optimising and scaling mRNA process development for next-generation medicines.

Get to market faster with CPI

At CPI, we accelerate the development and scale-up of mRNA-based therapeutics, providing the expertise, infrastructure, and process optimisation needed to support pre-clinical research and GMP manufacturing for clinical trials.

Our advanced bioprocessing, formulation, and lipid nanoparticle (LNP) encapsulation capabilities enable the efficient production of high-quality mRNA, ensuring stability, purity, and scalability. Whether optimising RNA synthesis, purification, or delivery technologies, we provide the tools and expertise to de-risk your journey from discovery to clinical trials.

mRNA strand.

mRNA therapeutics

Optimising and scaling mRNA process development for next-generation medicines.

Get to market faster with CPI

At CPI, we accelerate the development and scale-up of mRNA-based therapeutics, providing the expertise, infrastructure, and process optimisation needed to support pre-clinical research and GMP manufacturing for clinical trials.

Our advanced bioprocessing, formulation, and lipid nanoparticle (LNP) encapsulation capabilities enable the efficient production of high-quality mRNA, ensuring stability, purity, and scalability. Whether optimising RNA synthesis, purification, or delivery technologies, we provide the tools and expertise to de-risk your journey from discovery to clinical trials.

mRNA strand.

mRNA therapeutics

Optimising and scaling mRNA process development for next-generation medicines.

Get to market faster with CPI

At CPI, we accelerate the development and scale-up of mRNA-based therapeutics, providing the expertise, infrastructure, and process optimisation needed to support pre-clinical research and GMP manufacturing for clinical trials.

Our advanced bioprocessing, formulation, and lipid nanoparticle (LNP) encapsulation capabilities enable the efficient production of high-quality mRNA, ensuring stability, purity, and scalability. Whether optimising RNA synthesis, purification, or delivery technologies, we provide the tools and expertise to de-risk your journey from discovery to clinical trials.

  • SGS Quay Pharma
  • BoobyBiome
  • RNAssist
  • Intract Pharma
  • Pharmidex
  • AstraZeneca

What we offer

Whether you need technical expertise, lab-based development, process optimisation, or regulatory guidance, our tailored approach ensures you have the right support at every stage.

What we offer

Whether you need technical expertise, lab-based development, process optimisation, or regulatory guidance, our tailored approach ensures you have the right support at every stage.

What we offer

Whether you need technical expertise, lab-based development, process optimisation, or regulatory guidance, our tailored approach ensures you have the right support at every stage.

mRNA process development and scale-up

Accelerate your mRNA therapeutics pipeline with our advanced development and scale-up solutions:

  • Enzymatic synthesis of natural and modified mRNA.

  • Advanced capping technologies for improved stability.

  • Optimised purification via filtration and chromatography.

  • High-throughput bioreactor systems for process scalability.

  • RNA characterisation and integrity assessments.

These capabilities ensure efficient, high-yield mRNA production for preclinical and clinical applications.

mRNA process development and scale-up

Accelerate your mRNA therapeutics pipeline with our advanced development and scale-up solutions:

  • Enzymatic synthesis of natural and modified mRNA.

  • Advanced capping technologies for improved stability.

  • Optimised purification via filtration and chromatography.

  • High-throughput bioreactor systems for process scalability.

  • RNA characterisation and integrity assessments.

These capabilities ensure efficient, high-yield mRNA production for preclinical and clinical applications.

Lipid nanoparticle (LNP) encapsulation and downstream processing

Enhance mRNA delivery and stability with our LNP formulation and processing expertise: 

  • Formulation development for encapsulated mRNA with cryoprotectants.

  • Freeze-drying to improve product stability.

  • Microfluidic and T-Piece systems for precise mixing technologies.

  • GMP-compliant downstream processing, including TFF, dialysis, and filtration.

  • Particle characterisation and stability testing under varied conditions.

These capabilities support mRNA vaccine and therapeutic development, ensuring effective drug delivery.

Lipid nanoparticle (LNP) encapsulation and downstream processing

Enhance mRNA delivery and stability with our LNP formulation and processing expertise: 

  • Formulation development for encapsulated mRNA with cryoprotectants.

  • Freeze-drying to improve product stability.

  • Microfluidic and T-Piece systems for precise mixing technologies.

  • GMP-compliant downstream processing, including TFF, dialysis, and filtration.

  • Particle characterisation and stability testing under varied conditions.

These capabilities support mRNA vaccine and therapeutic development, ensuring effective drug delivery.

mRNA supply for toxicology and clinical studies

Secure high-quality mRNA materials for preclinical and early-stage clinical research:

  • Production scales from 1 mg to 20 g for preclinical applications.

  • GMP and non-GMP synthesis for toxicology and Phase 1 clinical studies.

  • Integration with supply chain partners for seamless drug product manufacturing.

  • Quality management services, including ‘Qualified Person’ product release. 

We ensure your mRNA-LNP formulations meet the highest quality and regulatory standards.

mRNA supply for toxicology and clinical studies

Secure high-quality mRNA materials for preclinical and early-stage clinical research:

  • Production scales from 1 mg to 20 g for preclinical applications.

  • GMP and non-GMP synthesis for toxicology and Phase 1 clinical studies.

  • Integration with supply chain partners for seamless drug product manufacturing.

  • Quality management services, including ‘Qualified Person’ product release. 

We ensure your mRNA-LNP formulations meet the highest quality and regulatory standards.

mRNA therapeutics applications

We enable innovation across a wide range of mRNA applications.

Close-up of gloved hands inserting a syringe needle into a clear medical vial.

mRNA therapeutics applications

We enable innovation across a wide range of mRNA applications.

Close-up of gloved hands inserting a syringe needle into a clear medical vial.

mRNA therapeutics applications

We enable innovation across a wide range of mRNA applications.

Close-up of gloved hands inserting a syringe needle into a clear medical vial.

How we support you

From discovery to commercialisation, we enable scalable, cost-effective, and regulatory-compliant pharmaceutical innovations.

How we support you

From discovery to commercialisation, we enable scalable, cost-effective, and regulatory-compliant pharmaceutical innovations.

How we support you

From discovery to commercialisation, we enable scalable, cost-effective, and regulatory-compliant pharmaceutical innovations.

Demonstrate the benefits of your mRNA innovation

Leverage our expertise, tools, and infrastructure to accelerate early-stage development with:

  • Rapid, cost-effective mRNA process development to support funding and investment.

  • Evaluation of mRNA-LNP formulations in industry-relevant settings.

  • Optimisation of mRNA therapies for enhanced efficacy and stability.

Demonstrate the benefits of your mRNA innovation

Leverage our expertise, tools, and infrastructure to accelerate early-stage development with:

  • Rapid, cost-effective mRNA process development to support funding and investment.

  • Evaluation of mRNA-LNP formulations in industry-relevant settings.

  • Optimisation of mRNA therapies for enhanced efficacy and stability.

Prove manufacturability and scalability

Ensure your mRNA therapies are scalable and reproducible with our advanced processing expertise. With CPI, you can access: 

  • Early-stage manufacturability assessments to evaluate production feasibility.

  • Process optimisation for cost-effective, high-yield mRNA synthesis.

  • Scalable production methods supporting preclinical and clinical development.

Prove manufacturability and scalability

Ensure your mRNA therapies are scalable and reproducible with our advanced processing expertise. With CPI, you can access: 

  • Early-stage manufacturability assessments to evaluate production feasibility.

  • Process optimisation for cost-effective, high-yield mRNA synthesis.

  • Scalable production methods supporting preclinical and clinical development.

Assess and demonstrate commercial viability

We provide data-driven insights and process validation to secure investment and commercial partnerships. We support with:

  • Commercial feasibility assessments for mRNA-based therapeutics.

  • Evaluation of scale-up processes to secure funding or licensing deals.

  • Transitioning from preclinical development to commercial production.

Assess and demonstrate commercial viability

We provide data-driven insights and process validation to secure investment and commercial partnerships. We support with:

  • Commercial feasibility assessments for mRNA-based therapeutics.

  • Evaluation of scale-up processes to secure funding or licensing deals.

  • Transitioning from preclinical development to commercial production.

Streamline regulatory compliance

We help to de-risk regulatory pathways, ensuring compliance with global standards. Our experts provide:

  • GMP-compliant mRNA production facilities.

  • Regulatory support for EMA, FDA, and MHRA approvals.

  • Quality assurance and documentation to mitigate risk.

Streamline regulatory compliance

We help to de-risk regulatory pathways, ensuring compliance with global standards. Our experts provide:

  • GMP-compliant mRNA production facilities.

  • Regulatory support for EMA, FDA, and MHRA approvals.

  • Quality assurance and documentation to mitigate risk.

Secure strategic partnerships

As a trusted UK government partner, we have built a broad network across global leaders, emerging companies, large corporates, healthcare, and academia. We help you to:

  • Access world-class mRNA manufacturing partners.

  • Build robust supply chains for drug product production.

  • Collaborate on industry-wide mRNA innovation challenges.

Secure strategic partnerships

As a trusted UK government partner, we have built a broad network across global leaders, emerging companies, large corporates, healthcare, and academia. We help you to:

  • Access world-class mRNA manufacturing partners.

  • Build robust supply chains for drug product production.

  • Collaborate on industry-wide mRNA innovation challenges.

  • Stainless steel process equipment skid installed in a pharmaceutical cleanroom.
    White oval tablets in the tray of a pharmaceutical counting and inspection machine.
  • Gowned scientist using a pipette to transfer a sample into a tube inside a laminar flow hood.
    CPI scientist in a lab coat and safety glasses using a pipette at a laboratory bench.
  • CPI scientist in a blue lab coat operating an ambr 250 automated bioreactor system with a tablet.
  • Row of capped glass vials moving along a pharmaceutical filling line.
    CPI scientist in safety glasses using a pipette to handle a pink sample in a laboratory.
  • CPI scientist drawing a process diagram on a glass screen in a laboratory.
    CPI scientists in blue lab coats operating analytical equipment in a laboratory.
  • Gloved hand placing a strip of PCR tubes containing blue liquid into a thermal cycler.
  • Stainless steel process equipment skid installed in a pharmaceutical cleanroom.
    White oval tablets in the tray of a pharmaceutical counting and inspection machine.
  • Gowned scientist using a pipette to transfer a sample into a tube inside a laminar flow hood.
    CPI scientist in a lab coat and safety glasses using a pipette at a laboratory bench.
  • CPI scientist in a blue lab coat operating an ambr 250 automated bioreactor system with a tablet.
  • Row of capped glass vials moving along a pharmaceutical filling line.
    CPI scientist in safety glasses using a pipette to handle a pink sample in a laboratory.
  • CPI scientist drawing a process diagram on a glass screen in a laboratory.
    CPI scientists in blue lab coats operating analytical equipment in a laboratory.
  • Gloved hand placing a strip of PCR tubes containing blue liquid into a thermal cycler.
  • Stainless steel process equipment skid installed in a pharmaceutical cleanroom.
    White oval tablets in the tray of a pharmaceutical counting and inspection machine.
  • Gowned scientist using a pipette to transfer a sample into a tube inside a laminar flow hood.
    CPI scientist in a lab coat and safety glasses using a pipette at a laboratory bench.
  • CPI scientist in a blue lab coat operating an ambr 250 automated bioreactor system with a tablet.
  • Row of capped glass vials moving along a pharmaceutical filling line.
    CPI scientist in safety glasses using a pipette to handle a pink sample in a laboratory.
  • CPI scientist drawing a process diagram on a glass screen in a laboratory.
    CPI scientists in blue lab coats operating analytical equipment in a laboratory.
  • Gloved hand placing a strip of PCR tubes containing blue liquid into a thermal cycler.
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Trusted by leading organisations

Showing slide 1 of 1
BoobyBiome

CPI was an excellent partner, aiding in demonstrating the manufacturing feasibility of our top bacterial candidates and distinguishing between strains in co-cultures. Their facilities in Darlington were impressive, facilitating rapid data generation. We’re now collaborating with CPI again to complete our preclinical program and prepare for the launch of our symbiotic supplement. I am excited to see this hard work translate into improved health for the next generation of infants!

Headshot of Lydia Mapstone, CEO

Lydia Mapstone

CEO

RNAssist

With CPI, we’ve shown that ambient-stable vaccine formulations are achievable, enabling global vaccine equity. CPI’s expertise, including proving the large-scale manufacturability of our TheraPHIX™ stabiliser, has advanced us far faster than we could have managed alone, giving us the credibility to aim for widespread adoption by vaccine manufacturers worldwide.

Headshot of Andrew Goldsborough, CEO

Andrew Goldsborough

CEO

Intract Pharma

Thanks to the expertise in drug development and manufacture brought by the colleagues from Quay, CPI and Pharmidex, we successfully developed a scalable manufacturing process for oral antibody products.

Headshot of Silvia Matiz, Formulation Scientist

Silvia Matiz

Formulation Scientist

AstraZeneca

With digital tools we can build in operational excellence right from the start of pharmaceutical development, improve product robustness, and drive more efficient manufacturing processes to deliver more medicines to more patients, more quickly.

Headshot of Sophie Bailes, Director Digital Transformation

Sophie Bailes

Director Digital Transformation

4basebio

CPI helped us accelerate a vital aspect of our manufacturing process to expedite our journey towards a clinical product. We’ve made significant progress in our GMP manufacturing capabilities, leading to our first DNA sales and increased interest in our products from partners and client base.

Headshot of Carmen Mañas Torres, Team Leader in Synthetic DNA Purification

Carmen Mañas Torres

Team Leader in Synthetic DNA Purification

Immune Boost Clinic

Manufacturing is just one part of the process, and CPI does so much more than just that. Growing mycolicibacteria consistently and reliably to food grade standard and combining them with other ingredients is difficult and requires attention to detail, expertise and experience from your partner.

Headshot of Tim Dye, Senior Scientific and Operations Advisor

Tim Dye

Senior Scientific and Operations Advisor

Trusted by leading organisations

Showing slide 1 of 1
BoobyBiome

CPI was an excellent partner, aiding in demonstrating the manufacturing feasibility of our top bacterial candidates and distinguishing between strains in co-cultures. Their facilities in Darlington were impressive, facilitating rapid data generation. We’re now collaborating with CPI again to complete our preclinical program and prepare for the launch of our symbiotic supplement. I am excited to see this hard work translate into improved health for the next generation of infants!

Headshot of Lydia Mapstone, CEO

Lydia Mapstone

CEO

RNAssist

With CPI, we’ve shown that ambient-stable vaccine formulations are achievable, enabling global vaccine equity. CPI’s expertise, including proving the large-scale manufacturability of our TheraPHIX™ stabiliser, has advanced us far faster than we could have managed alone, giving us the credibility to aim for widespread adoption by vaccine manufacturers worldwide.

Headshot of Andrew Goldsborough, CEO

Andrew Goldsborough

CEO

Intract Pharma

Thanks to the expertise in drug development and manufacture brought by the colleagues from Quay, CPI and Pharmidex, we successfully developed a scalable manufacturing process for oral antibody products.

Headshot of Silvia Matiz, Formulation Scientist

Silvia Matiz

Formulation Scientist

AstraZeneca

With digital tools we can build in operational excellence right from the start of pharmaceutical development, improve product robustness, and drive more efficient manufacturing processes to deliver more medicines to more patients, more quickly.

Headshot of Sophie Bailes, Director Digital Transformation

Sophie Bailes

Director Digital Transformation

4basebio

CPI helped us accelerate a vital aspect of our manufacturing process to expedite our journey towards a clinical product. We’ve made significant progress in our GMP manufacturing capabilities, leading to our first DNA sales and increased interest in our products from partners and client base.

Headshot of Carmen Mañas Torres, Team Leader in Synthetic DNA Purification

Carmen Mañas Torres

Team Leader in Synthetic DNA Purification

Immune Boost Clinic

Manufacturing is just one part of the process, and CPI does so much more than just that. Growing mycolicibacteria consistently and reliably to food grade standard and combining them with other ingredients is difficult and requires attention to detail, expertise and experience from your partner.

Headshot of Tim Dye, Senior Scientific and Operations Advisor

Tim Dye

Senior Scientific and Operations Advisor

Trusted by leading organisations

Showing slide 1 of 1
BoobyBiome

CPI was an excellent partner, aiding in demonstrating the manufacturing feasibility of our top bacterial candidates and distinguishing between strains in co-cultures. Their facilities in Darlington were impressive, facilitating rapid data generation. We’re now collaborating with CPI again to complete our preclinical program and prepare for the launch of our symbiotic supplement. I am excited to see this hard work translate into improved health for the next generation of infants!

Headshot of Lydia Mapstone, CEO

Lydia Mapstone

CEO

RNAssist

With CPI, we’ve shown that ambient-stable vaccine formulations are achievable, enabling global vaccine equity. CPI’s expertise, including proving the large-scale manufacturability of our TheraPHIX™ stabiliser, has advanced us far faster than we could have managed alone, giving us the credibility to aim for widespread adoption by vaccine manufacturers worldwide.

Headshot of Andrew Goldsborough, CEO

Andrew Goldsborough

CEO

Intract Pharma

Thanks to the expertise in drug development and manufacture brought by the colleagues from Quay, CPI and Pharmidex, we successfully developed a scalable manufacturing process for oral antibody products.

Headshot of Silvia Matiz, Formulation Scientist

Silvia Matiz

Formulation Scientist

AstraZeneca

With digital tools we can build in operational excellence right from the start of pharmaceutical development, improve product robustness, and drive more efficient manufacturing processes to deliver more medicines to more patients, more quickly.

Headshot of Sophie Bailes, Director Digital Transformation

Sophie Bailes

Director Digital Transformation

4basebio

CPI helped us accelerate a vital aspect of our manufacturing process to expedite our journey towards a clinical product. We’ve made significant progress in our GMP manufacturing capabilities, leading to our first DNA sales and increased interest in our products from partners and client base.

Headshot of Carmen Mañas Torres, Team Leader in Synthetic DNA Purification

Carmen Mañas Torres

Team Leader in Synthetic DNA Purification

Immune Boost Clinic

Manufacturing is just one part of the process, and CPI does so much more than just that. Growing mycolicibacteria consistently and reliably to food grade standard and combining them with other ingredients is difficult and requires attention to detail, expertise and experience from your partner.

Headshot of Tim Dye, Senior Scientific and Operations Advisor

Tim Dye

Senior Scientific and Operations Advisor

Get in touch

Get in touch

Get in touch