Oral solid dose formulation and process development

Optimising solid dosage forms for enhanced drug delivery and manufacturing efficiency.

Get to market faster with CPI

At CPI, we support the development, optimisation, and scale-up of oral solid dose (OSD) formulations to improve bioavailability, stability, and manufacturability. 

Our expertise in tablet production, in-process monitoring, and advanced analytics helps you streamline development, support regulatory compliance, and scale efficiently. Whether optimising controlled-release profiles, improving solubility, or adopting continuous manufacturing technologies such as Continuous Direct Compression (CDC), we provide the infrastructure and insight to accelerate your path from formulation to commercialisation. 

Pink pills during production and packing process.

Oral solid dose formulation and process development

Optimising solid dosage forms for enhanced drug delivery and manufacturing efficiency.

Get to market faster with CPI

At CPI, we support the development, optimisation, and scale-up of oral solid dose (OSD) formulations to improve bioavailability, stability, and manufacturability. 

Our expertise in tablet production, in-process monitoring, and advanced analytics helps you streamline development, support regulatory compliance, and scale efficiently. Whether optimising controlled-release profiles, improving solubility, or adopting continuous manufacturing technologies such as Continuous Direct Compression (CDC), we provide the infrastructure and insight to accelerate your path from formulation to commercialisation. 

Pink pills during production and packing process.

Oral solid dose formulation and process development

Optimising solid dosage forms for enhanced drug delivery and manufacturing efficiency.

Get to market faster with CPI

At CPI, we support the development, optimisation, and scale-up of oral solid dose (OSD) formulations to improve bioavailability, stability, and manufacturability. 

Our expertise in tablet production, in-process monitoring, and advanced analytics helps you streamline development, support regulatory compliance, and scale efficiently. Whether optimising controlled-release profiles, improving solubility, or adopting continuous manufacturing technologies such as Continuous Direct Compression (CDC), we provide the infrastructure and insight to accelerate your path from formulation to commercialisation. 

  • SGS Quay Pharma
  • BoobyBiome
  • RNAssist
  • Intract Pharma
  • Pharmidex
  • AstraZeneca

What we offer

Whether you need technical consultancy, lab-based development, process optimisation or digitalisation support, our tailored approach ensures you have the right expertise at every stage.

What we offer

Whether you need technical consultancy, lab-based development, process optimisation or digitalisation support, our tailored approach ensures you have the right expertise at every stage.

What we offer

Whether you need technical consultancy, lab-based development, process optimisation or digitalisation support, our tailored approach ensures you have the right expertise at every stage.

Characterisation of raw material properties

Optimise raw material selection and processing with our analytical capabilities: 

  • Particle size distribution (PSD) and morphology analysis. 

  • Flowability, compressibility, and moisture content assessment. 

  • Crystallinity and polymorphism studies. 

  • Physical and chemical stability testing. 

  • Chemical purity assessments. 

These analyses underpin robust formulation design and consistent product performance. 

Characterisation of raw material properties

Optimise raw material selection and processing with our analytical capabilities: 

  • Particle size distribution (PSD) and morphology analysis. 

  • Flowability, compressibility, and moisture content assessment. 

  • Crystallinity and polymorphism studies. 

  • Physical and chemical stability testing. 

  • Chemical purity assessments. 

These analyses underpin robust formulation design and consistent product performance. 

Powder blend characterisation and optimisation

Ensure blend uniformity and formulation stability with our support in: 

  • Blend and content uniformity testing. 

  • Granulation and dry mixing optimisation. 

  • Shear sensitivity and powder flow studies. 

  • Moisture sorption/ desorption analysis. 

  • Development for scale-up and semi-continuous/continuous manufacturing. 

These insights enhance efficiency and product quality across the development lifecycle. 

Powder blend characterisation and optimisation

Ensure blend uniformity and formulation stability with our support in: 

  • Blend and content uniformity testing. 

  • Granulation and dry mixing optimisation. 

  • Shear sensitivity and powder flow studies. 

  • Moisture sorption/ desorption analysis. 

  • Development for scale-up and semi-continuous/continuous manufacturing. 

These insights enhance efficiency and product quality across the development lifecycle. 

Tablet and capsule development, manufacture, and characterisation

We help you optimise tablet and capsule manufacture for performance and scale: 

  • Formulation development for dissolution, bioavailability, and flowability. 

  • Tablet hardness, friability, and disintegration testing. 

  • Dissolution and release kinetics studies. 

  • Compression and compaction profile optimisation. 

  • Coating technologies for taste masking or modified release.  

Our support ensures robust, scalable, and patient-friendly solid dose products. 

Tablet and capsule development, manufacture, and characterisation

We help you optimise tablet and capsule manufacture for performance and scale: 

  • Formulation development for dissolution, bioavailability, and flowability. 

  • Tablet hardness, friability, and disintegration testing. 

  • Dissolution and release kinetics studies. 

  • Compression and compaction profile optimisation. 

  • Coating technologies for taste masking or modified release.  

Our support ensures robust, scalable, and patient-friendly solid dose products. 

Process analytical technology (PAT) for in-line monitoring and control

Develop real-time control strategies with advanced process monitoring tools: 

  • CDC to reduce complexity and improve efficiency. 

  • NIR and Raman spectroscopy for in-line monitoring — including blend uniformity prior to tableting. 

  • Granulation and drying endpoint determination. 

  • Process control strategies for continuous manufacturing. 

  • Data analytics and digital modelling for process optimisation. 

  • QbD implementation to support regulatory readiness. 

Process analytical technology (PAT) for in-line monitoring and control

Develop real-time control strategies with advanced process monitoring tools: 

  • CDC to reduce complexity and improve efficiency. 

  • NIR and Raman spectroscopy for in-line monitoring — including blend uniformity prior to tableting. 

  • Granulation and drying endpoint determination. 

  • Process control strategies for continuous manufacturing. 

  • Data analytics and digital modelling for process optimisation. 

  • QbD implementation to support regulatory readiness. 

Sustainable manufacturing

Reduce environmental impact while boosting efficiency: 

  • Implement CDC to eliminate energy-intensive steps like granulation. 

  • Reduce water, material use and waste through first-intent CDC. 

  • Conduct Life Cycle Analysis to target Scope 1–3 emissions reductions. 

  • Use digital twins to predict tablet quality from material and process settings. 

  • Automate processes for continuous direct manufacturing. 

We help you reduce variability, lower emissions, and drive sustainable innovation. 

Sustainable manufacturing

Reduce environmental impact while boosting efficiency: 

  • Implement CDC to eliminate energy-intensive steps like granulation. 

  • Reduce water, material use and waste through first-intent CDC. 

  • Conduct Life Cycle Analysis to target Scope 1–3 emissions reductions. 

  • Use digital twins to predict tablet quality from material and process settings. 

  • Automate processes for continuous direct manufacturing. 

We help you reduce variability, lower emissions, and drive sustainable innovation. 

Oral solid dose formulation and process development applications

We enable innovation across a wide range of oral solid dose through various processes and operations.

Rows of white tablets on a rotary tablet press during pharmaceutical production.

Oral solid dose formulation and process development applications

We enable innovation across a wide range of oral solid dose through various processes and operations.

Rows of white tablets on a rotary tablet press during pharmaceutical production.

Oral solid dose formulation and process development applications

We enable innovation across a wide range of oral solid dose through various processes and operations.

Rows of white tablets on a rotary tablet press during pharmaceutical production.

How we support you

From discovery to commercialisation, we enable sustainable, scalable, and profitable pharmaceutical innovations.

How we support you

From discovery to commercialisation, we enable sustainable, scalable, and profitable pharmaceutical innovations.

How we support you

From discovery to commercialisation, we enable sustainable, scalable, and profitable pharmaceutical innovations.

Demonstrate the benefits of your oral solid dose formulation

Accelerate development and showcase product potential through: 

  • Rapid, cost-effective formulation optimisation. 

  • Validation in real-world, industry-relevant environments. 

  • Improved bioavailability, stability, and patient outcomes. 

Demonstrate the benefits of your oral solid dose formulation

Accelerate development and showcase product potential through: 

  • Rapid, cost-effective formulation optimisation. 

  • Validation in real-world, industry-relevant environments. 

  • Improved bioavailability, stability, and patient outcomes. 

Prove manufacturability and scalability

Build confidence in your path to market with: 

  • Feasibility assessments for early manufacturability. 

  • Scalable process development tailored for clinical and commercial readiness. 

  • Integration of continuous technologies to streamline scale-up.

Prove manufacturability and scalability

Build confidence in your path to market with: 

  • Feasibility assessments for early manufacturability. 

  • Scalable process development tailored for clinical and commercial readiness. 

  • Integration of continuous technologies to streamline scale-up.

Assess and demonstrate commercial viability

We generate the technical and economic evidence needed to secure investment and partnerships: 

  • Commercial feasibility studies for oral solid dose formulations. 

Assess and demonstrate commercial viability

We generate the technical and economic evidence needed to secure investment and partnerships: 

  • Commercial feasibility studies for oral solid dose formulations. 

Streamline regulatory compliance

De-risk your regulatory journey with support from experts in: 

  • GMP-aligned development and manufacturing facilities. 

  • Quality documentation aligned with international standards. 

Streamline regulatory compliance

De-risk your regulatory journey with support from experts in: 

  • GMP-aligned development and manufacturing facilities. 

  • Quality documentation aligned with international standards. 

Secure strategic partnerships

As a trusted UK government partner, we have built a broad network across global leaders, emerging companies, large corporates, healthcare, and academia. We help you to: 

  • Access world-class solid dose formulation experts and manufacturing partners. 

  • Build robust supply chains for tablet and capsule production. 

  • Collaborate on industry-wide solid dose innovation challenges. 

Secure strategic partnerships

As a trusted UK government partner, we have built a broad network across global leaders, emerging companies, large corporates, healthcare, and academia. We help you to: 

  • Access world-class solid dose formulation experts and manufacturing partners. 

  • Build robust supply chains for tablet and capsule production. 

  • Collaborate on industry-wide solid dose innovation challenges. 

  • Stainless steel process equipment skid installed in a pharmaceutical cleanroom.
    White oval tablets in the tray of a pharmaceutical counting and inspection machine.
  • Gowned scientist using a pipette to transfer a sample into a tube inside a laminar flow hood.
    CPI scientist in a lab coat and safety glasses using a pipette at a laboratory bench.
  • CPI scientist in a blue lab coat operating an ambr 250 automated bioreactor system with a tablet.
  • Row of capped glass vials moving along a pharmaceutical filling line.
    CPI scientist in safety glasses using a pipette to handle a pink sample in a laboratory.
  • CPI scientist drawing a process diagram on a glass screen in a laboratory.
    CPI scientists in blue lab coats operating analytical equipment in a laboratory.
  • Gloved hand placing a strip of PCR tubes containing blue liquid into a thermal cycler.
  • Stainless steel process equipment skid installed in a pharmaceutical cleanroom.
    White oval tablets in the tray of a pharmaceutical counting and inspection machine.
  • Gowned scientist using a pipette to transfer a sample into a tube inside a laminar flow hood.
    CPI scientist in a lab coat and safety glasses using a pipette at a laboratory bench.
  • CPI scientist in a blue lab coat operating an ambr 250 automated bioreactor system with a tablet.
  • Row of capped glass vials moving along a pharmaceutical filling line.
    CPI scientist in safety glasses using a pipette to handle a pink sample in a laboratory.
  • CPI scientist drawing a process diagram on a glass screen in a laboratory.
    CPI scientists in blue lab coats operating analytical equipment in a laboratory.
  • Gloved hand placing a strip of PCR tubes containing blue liquid into a thermal cycler.
  • Stainless steel process equipment skid installed in a pharmaceutical cleanroom.
    White oval tablets in the tray of a pharmaceutical counting and inspection machine.
  • Gowned scientist using a pipette to transfer a sample into a tube inside a laminar flow hood.
    CPI scientist in a lab coat and safety glasses using a pipette at a laboratory bench.
  • CPI scientist in a blue lab coat operating an ambr 250 automated bioreactor system with a tablet.
  • Row of capped glass vials moving along a pharmaceutical filling line.
    CPI scientist in safety glasses using a pipette to handle a pink sample in a laboratory.
  • CPI scientist drawing a process diagram on a glass screen in a laboratory.
    CPI scientists in blue lab coats operating analytical equipment in a laboratory.
  • Gloved hand placing a strip of PCR tubes containing blue liquid into a thermal cycler.
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Trusted by leading organisations

Showing slide 1 of 1
BoobyBiome

CPI was an excellent partner, aiding in demonstrating the manufacturing feasibility of our top bacterial candidates and distinguishing between strains in co-cultures. Their facilities in Darlington were impressive, facilitating rapid data generation. We’re now collaborating with CPI again to complete our preclinical program and prepare for the launch of our symbiotic supplement. I am excited to see this hard work translate into improved health for the next generation of infants!

Headshot of Lydia Mapstone, CEO

Lydia Mapstone

CEO

RNAssist

With CPI, we’ve shown that ambient-stable vaccine formulations are achievable, enabling global vaccine equity. CPI’s expertise, including proving the large-scale manufacturability of our TheraPHIX™ stabiliser, has advanced us far faster than we could have managed alone, giving us the credibility to aim for widespread adoption by vaccine manufacturers worldwide.

Headshot of Andrew Goldsborough, CEO

Andrew Goldsborough

CEO

Intract Pharma

Thanks to the expertise in drug development and manufacture brought by the colleagues from Quay, CPI and Pharmidex, we successfully developed a scalable manufacturing process for oral antibody products.

Headshot of Silvia Matiz, Formulation Scientist

Silvia Matiz

Formulation Scientist

AstraZeneca

With digital tools we can build in operational excellence right from the start of pharmaceutical development, improve product robustness, and drive more efficient manufacturing processes to deliver more medicines to more patients, more quickly.

Headshot of Sophie Bailes, Director Digital Transformation

Sophie Bailes

Director Digital Transformation

4basebio

CPI helped us accelerate a vital aspect of our manufacturing process to expedite our journey towards a clinical product. We’ve made significant progress in our GMP manufacturing capabilities, leading to our first DNA sales and increased interest in our products from partners and client base.

Headshot of Carmen Mañas Torres, Team Leader in Synthetic DNA Purification

Carmen Mañas Torres

Team Leader in Synthetic DNA Purification

Immune Boost Clinic

Manufacturing is just one part of the process, and CPI does so much more than just that. Growing mycolicibacteria consistently and reliably to food grade standard and combining them with other ingredients is difficult and requires attention to detail, expertise and experience from your partner.

Headshot of Tim Dye, Senior Scientific and Operations Advisor

Tim Dye

Senior Scientific and Operations Advisor

Trusted by leading organisations

Showing slide 1 of 1
BoobyBiome

CPI was an excellent partner, aiding in demonstrating the manufacturing feasibility of our top bacterial candidates and distinguishing between strains in co-cultures. Their facilities in Darlington were impressive, facilitating rapid data generation. We’re now collaborating with CPI again to complete our preclinical program and prepare for the launch of our symbiotic supplement. I am excited to see this hard work translate into improved health for the next generation of infants!

Headshot of Lydia Mapstone, CEO

Lydia Mapstone

CEO

RNAssist

With CPI, we’ve shown that ambient-stable vaccine formulations are achievable, enabling global vaccine equity. CPI’s expertise, including proving the large-scale manufacturability of our TheraPHIX™ stabiliser, has advanced us far faster than we could have managed alone, giving us the credibility to aim for widespread adoption by vaccine manufacturers worldwide.

Headshot of Andrew Goldsborough, CEO

Andrew Goldsborough

CEO

Intract Pharma

Thanks to the expertise in drug development and manufacture brought by the colleagues from Quay, CPI and Pharmidex, we successfully developed a scalable manufacturing process for oral antibody products.

Headshot of Silvia Matiz, Formulation Scientist

Silvia Matiz

Formulation Scientist

AstraZeneca

With digital tools we can build in operational excellence right from the start of pharmaceutical development, improve product robustness, and drive more efficient manufacturing processes to deliver more medicines to more patients, more quickly.

Headshot of Sophie Bailes, Director Digital Transformation

Sophie Bailes

Director Digital Transformation

4basebio

CPI helped us accelerate a vital aspect of our manufacturing process to expedite our journey towards a clinical product. We’ve made significant progress in our GMP manufacturing capabilities, leading to our first DNA sales and increased interest in our products from partners and client base.

Headshot of Carmen Mañas Torres, Team Leader in Synthetic DNA Purification

Carmen Mañas Torres

Team Leader in Synthetic DNA Purification

Immune Boost Clinic

Manufacturing is just one part of the process, and CPI does so much more than just that. Growing mycolicibacteria consistently and reliably to food grade standard and combining them with other ingredients is difficult and requires attention to detail, expertise and experience from your partner.

Headshot of Tim Dye, Senior Scientific and Operations Advisor

Tim Dye

Senior Scientific and Operations Advisor

Trusted by leading organisations

Showing slide 1 of 1
BoobyBiome

CPI was an excellent partner, aiding in demonstrating the manufacturing feasibility of our top bacterial candidates and distinguishing between strains in co-cultures. Their facilities in Darlington were impressive, facilitating rapid data generation. We’re now collaborating with CPI again to complete our preclinical program and prepare for the launch of our symbiotic supplement. I am excited to see this hard work translate into improved health for the next generation of infants!

Headshot of Lydia Mapstone, CEO

Lydia Mapstone

CEO

RNAssist

With CPI, we’ve shown that ambient-stable vaccine formulations are achievable, enabling global vaccine equity. CPI’s expertise, including proving the large-scale manufacturability of our TheraPHIX™ stabiliser, has advanced us far faster than we could have managed alone, giving us the credibility to aim for widespread adoption by vaccine manufacturers worldwide.

Headshot of Andrew Goldsborough, CEO

Andrew Goldsborough

CEO

Intract Pharma

Thanks to the expertise in drug development and manufacture brought by the colleagues from Quay, CPI and Pharmidex, we successfully developed a scalable manufacturing process for oral antibody products.

Headshot of Silvia Matiz, Formulation Scientist

Silvia Matiz

Formulation Scientist

AstraZeneca

With digital tools we can build in operational excellence right from the start of pharmaceutical development, improve product robustness, and drive more efficient manufacturing processes to deliver more medicines to more patients, more quickly.

Headshot of Sophie Bailes, Director Digital Transformation

Sophie Bailes

Director Digital Transformation

4basebio

CPI helped us accelerate a vital aspect of our manufacturing process to expedite our journey towards a clinical product. We’ve made significant progress in our GMP manufacturing capabilities, leading to our first DNA sales and increased interest in our products from partners and client base.

Headshot of Carmen Mañas Torres, Team Leader in Synthetic DNA Purification

Carmen Mañas Torres

Team Leader in Synthetic DNA Purification

Immune Boost Clinic

Manufacturing is just one part of the process, and CPI does so much more than just that. Growing mycolicibacteria consistently and reliably to food grade standard and combining them with other ingredients is difficult and requires attention to detail, expertise and experience from your partner.

Headshot of Tim Dye, Senior Scientific and Operations Advisor

Tim Dye

Senior Scientific and Operations Advisor

Get in touch

Get in touch

Get in touch