Oligonucleotides
Optimising the development and scale-up of oligonucleotide-based therapeutics.
Get to market faster with CPI
At CPI, we accelerate the development, optimisation, and scale-up of oligonucleotide therapies, enabling efficient and cost effective production of antisense oligonucleotides (ASOs), small interfering RNA (siRNA), oligo-conjugates through standard and new approaches including hybrid fragment synthesis and new synthesis methodologies.
With expertise in synthesis, purification, formulation, and analytical characterisation, we help you streamline oligonucleotide manufacturing while ensuring stability, scalability, and clinical readiness. Our state-of-the-art infrastructure and GMP-ready facilities support preclinical and clinical development, helping you bring next-generation therapies to market faster.

Oligonucleotides
Optimising the development and scale-up of oligonucleotide-based therapeutics.
Get to market faster with CPI
At CPI, we accelerate the development, optimisation, and scale-up of oligonucleotide therapies, enabling efficient and cost effective production of antisense oligonucleotides (ASOs), small interfering RNA (siRNA), oligo-conjugates through standard and new approaches including hybrid fragment synthesis and new synthesis methodologies.
With expertise in synthesis, purification, formulation, and analytical characterisation, we help you streamline oligonucleotide manufacturing while ensuring stability, scalability, and clinical readiness. Our state-of-the-art infrastructure and GMP-ready facilities support preclinical and clinical development, helping you bring next-generation therapies to market faster.

Oligonucleotides
Optimising the development and scale-up of oligonucleotide-based therapeutics.
Get to market faster with CPI
At CPI, we accelerate the development, optimisation, and scale-up of oligonucleotide therapies, enabling efficient and cost effective production of antisense oligonucleotides (ASOs), small interfering RNA (siRNA), oligo-conjugates through standard and new approaches including hybrid fragment synthesis and new synthesis methodologies.
With expertise in synthesis, purification, formulation, and analytical characterisation, we help you streamline oligonucleotide manufacturing while ensuring stability, scalability, and clinical readiness. Our state-of-the-art infrastructure and GMP-ready facilities support preclinical and clinical development, helping you bring next-generation therapies to market faster.
What we offer
Whether you need technical expertise, lab-based development, process optimisation, or regulatory guidance, our tailored approach ensures you have the right support at every stage.
What we offer
Whether you need technical expertise, lab-based development, process optimisation, or regulatory guidance, our tailored approach ensures you have the right support at every stage.
What we offer
Whether you need technical expertise, lab-based development, process optimisation, or regulatory guidance, our tailored approach ensures you have the right support at every stage.
Oligonucleotide process development and scale-up
Optimise and scale your oligonucleotide therapeutics with CPI’s expertise:
Synthesis of ASOs, siRNA and oligo-conjugates.
Optimisation of reaction conditions for enhanced yield and purity.
Enzymatic and chemical oligonucleotide synthesis technologies.
Downstream purification via anion exchange chromatography and ultrafiltration.
Techno-economic evaluation of novel synthesis and purification strategies.
Process development from milligram to gram-scale.
Process equipment including Cytiva’s OligoSynt™, Äkta Flux™, and Äkta Pure™.
These capabilities ensure cost-effective, scalable oligonucleotide manufacturing.
Oligonucleotide process development and scale-up
Optimise and scale your oligonucleotide therapeutics with CPI’s expertise:
Synthesis of ASOs, siRNA and oligo-conjugates.
Optimisation of reaction conditions for enhanced yield and purity.
Enzymatic and chemical oligonucleotide synthesis technologies.
Downstream purification via anion exchange chromatography and ultrafiltration.
Techno-economic evaluation of novel synthesis and purification strategies.
Process development from milligram to gram-scale.
Process equipment including Cytiva’s OligoSynt™, Äkta Flux™, and Äkta Pure™.
These capabilities ensure cost-effective, scalable oligonucleotide manufacturing.
Oligonucleotide analytical development and characterisation
Ensure the quality, integrity, and stability of your oligonucleotide-based therapeutics with CPI’s analytical expertise:
Purity analysis in our on-site QC lab with high resolution LC-MS.
LC-MS method development and validation.
Thermo Fisher Scientific Vanquish HPLC coupled to Exploris 120 or ISQ mass spectrometers for accurate molecular weight, purity and sequence information.
Additional test methods including UV-Vis spectrometer, Raman, GC and Endotoxin analysis.
Method development validation.
Supporting information for regulatory submissions.
These capabilities ensure compliance with stringent quality and regulatory standards.
Oligonucleotide analytical development and characterisation
Ensure the quality, integrity, and stability of your oligonucleotide-based therapeutics with CPI’s analytical expertise:
Purity analysis in our on-site QC lab with high resolution LC-MS.
LC-MS method development and validation.
Thermo Fisher Scientific Vanquish HPLC coupled to Exploris 120 or ISQ mass spectrometers for accurate molecular weight, purity and sequence information.
Additional test methods including UV-Vis spectrometer, Raman, GC and Endotoxin analysis.
Method development validation.
Supporting information for regulatory submissions.
These capabilities ensure compliance with stringent quality and regulatory standards.
GMP supply for preclinical and clinical studies
Secure high-quality oligonucleotides for early-stage development:
Scalable oligonucleotide production for gram scale (1–30 mmol) for pre-clinical studies.
Clinical-grade oligonucleotide synthesis at kg scale (10–150 mmol).
Cytiva’s OligoPilot™, Äktaprocess™ and Uniflux™ with supporting process equipment.
Electronic batch record and dedicated process transfer support.
Seamless integration with supply chain partners for formulation development and drug product manufacturing.
Evaluation and integration of new process technologies, including biocatalytic, liquid phase and fragment-based synthesis.
Full package of quality assurance services, including ‘Qualified Person’.
These capabilities support regulatory compliance and enable smooth progression from discovery to clinical trials.
GMP supply for preclinical and clinical studies
Secure high-quality oligonucleotides for early-stage development:
Scalable oligonucleotide production for gram scale (1–30 mmol) for pre-clinical studies.
Clinical-grade oligonucleotide synthesis at kg scale (10–150 mmol).
Cytiva’s OligoPilot™, Äktaprocess™ and Uniflux™ with supporting process equipment.
Electronic batch record and dedicated process transfer support.
Seamless integration with supply chain partners for formulation development and drug product manufacturing.
Evaluation and integration of new process technologies, including biocatalytic, liquid phase and fragment-based synthesis.
Full package of quality assurance services, including ‘Qualified Person’.
These capabilities support regulatory compliance and enable smooth progression from discovery to clinical trials.
Oligonucleotides applications
We enable innovation across a wide range of oligonucleotide and RNA therapeutics, including gene silencing and modulation treatments.

Oligonucleotides applications
We enable innovation across a wide range of oligonucleotide and RNA therapeutics, including gene silencing and modulation treatments.

Oligonucleotides applications
We enable innovation across a wide range of oligonucleotide and RNA therapeutics, including gene silencing and modulation treatments.

How we support you
From discovery to commercialisation, we enable scalable, cost-effective, and regulatory-compliant pharmaceutical innovations.
How we support you
From discovery to commercialisation, we enable scalable, cost-effective, and regulatory-compliant pharmaceutical innovations.
How we support you
From discovery to commercialisation, we enable scalable, cost-effective, and regulatory-compliant pharmaceutical innovations.
Demonstrate the benefits of your oligonucleotide innovation
Leverage our expertise to accelerate early-stage development and build investor confidence with:
Fast, cost-effective oligonucleotide process development to support funding and investment.
Demonstration of oligonucleotide processes in industry-relevant settings.
Demonstrate the benefits of your oligonucleotide innovation
Leverage our expertise to accelerate early-stage development and build investor confidence with:
Fast, cost-effective oligonucleotide process development to support funding and investment.
Demonstration of oligonucleotide processes in industry-relevant settings.
Prove manufacturability and scalability
Ensure your oligonucleotide therapies are reproducible and scalable with our advanced processing expertise. With CPI, you can access:
Early-stage manufacturability assessments for oligonucleotide production.
Process optimisation for yield, stability, and cost-effectiveness.
Scalable synthesis and purification methods for clinical readiness.
Prove manufacturability and scalability
Ensure your oligonucleotide therapies are reproducible and scalable with our advanced processing expertise. With CPI, you can access:
Early-stage manufacturability assessments for oligonucleotide production.
Process optimisation for yield, stability, and cost-effectiveness.
Scalable synthesis and purification methods for clinical readiness.
Assess and demonstrate commercial viability
We provide data-driven insights and process validation to secure investment and commercial partnerships. We support with:
Commercial feasibility assessments for oligonucleotide-based therapeutics.
Industrialisation of scale-up processes to secure funding or licensing deals.
Transitioning from preclinical development to commercial production.
Assess and demonstrate commercial viability
We provide data-driven insights and process validation to secure investment and commercial partnerships. We support with:
Commercial feasibility assessments for oligonucleotide-based therapeutics.
Industrialisation of scale-up processes to secure funding or licensing deals.
Transitioning from preclinical development to commercial production.
Secure strategic partnerships
As a trusted UK government partner, we have built a broad network across global leaders, emerging companies, large corporates, healthcare, and academia. We help you to:
Access our network of world-class technology providers, academic partners, and support for regulatory, raw material supply chain and downstream formulation partners.
Build robust supply chains for oligonucleotide drug production.
Collaborate on industry-wide oligonucleotide innovation challenges.
Secure strategic partnerships
As a trusted UK government partner, we have built a broad network across global leaders, emerging companies, large corporates, healthcare, and academia. We help you to:
Access our network of world-class technology providers, academic partners, and support for regulatory, raw material supply chain and downstream formulation partners.
Build robust supply chains for oligonucleotide drug production.
Collaborate on industry-wide oligonucleotide innovation challenges.
private investment unlocked
R&D projects delivered
years of experience
business collaborations
facilities
innovation assets
private investment unlocked
R&D projects delivered
years of experience
business collaborations
facilities
innovation assets
private investment unlocked
R&D projects delivered
years of experience
business collaborations
facilities
innovation assets
Trusted by leading organisations
CPI was an excellent partner, aiding in demonstrating the manufacturing feasibility of our top bacterial candidates and distinguishing between strains in co-cultures. Their facilities in Darlington were impressive, facilitating rapid data generation. We’re now collaborating with CPI again to complete our preclinical program and prepare for the launch of our symbiotic supplement. I am excited to see this hard work translate into improved health for the next generation of infants!

Lydia Mapstone
CEO
With CPI, we’ve shown that ambient-stable vaccine formulations are achievable, enabling global vaccine equity. CPI’s expertise, including proving the large-scale manufacturability of our TheraPHIX™ stabiliser, has advanced us far faster than we could have managed alone, giving us the credibility to aim for widespread adoption by vaccine manufacturers worldwide.

Andrew Goldsborough
CEO
Thanks to the expertise in drug development and manufacture brought by the colleagues from Quay, CPI and Pharmidex, we successfully developed a scalable manufacturing process for oral antibody products.

Silvia Matiz
Formulation Scientist
With digital tools we can build in operational excellence right from the start of pharmaceutical development, improve product robustness, and drive more efficient manufacturing processes to deliver more medicines to more patients, more quickly.

Sophie Bailes
Director Digital Transformation
CPI helped us accelerate a vital aspect of our manufacturing process to expedite our journey towards a clinical product. We’ve made significant progress in our GMP manufacturing capabilities, leading to our first DNA sales and increased interest in our products from partners and client base.

Carmen Mañas Torres
Team Leader in Synthetic DNA Purification
Manufacturing is just one part of the process, and CPI does so much more than just that. Growing mycolicibacteria consistently and reliably to food grade standard and combining them with other ingredients is difficult and requires attention to detail, expertise and experience from your partner.

Tim Dye
Senior Scientific and Operations Advisor
Trusted by leading organisations
CPI was an excellent partner, aiding in demonstrating the manufacturing feasibility of our top bacterial candidates and distinguishing between strains in co-cultures. Their facilities in Darlington were impressive, facilitating rapid data generation. We’re now collaborating with CPI again to complete our preclinical program and prepare for the launch of our symbiotic supplement. I am excited to see this hard work translate into improved health for the next generation of infants!

Lydia Mapstone
CEO
With CPI, we’ve shown that ambient-stable vaccine formulations are achievable, enabling global vaccine equity. CPI’s expertise, including proving the large-scale manufacturability of our TheraPHIX™ stabiliser, has advanced us far faster than we could have managed alone, giving us the credibility to aim for widespread adoption by vaccine manufacturers worldwide.

Andrew Goldsborough
CEO
Thanks to the expertise in drug development and manufacture brought by the colleagues from Quay, CPI and Pharmidex, we successfully developed a scalable manufacturing process for oral antibody products.

Silvia Matiz
Formulation Scientist
With digital tools we can build in operational excellence right from the start of pharmaceutical development, improve product robustness, and drive more efficient manufacturing processes to deliver more medicines to more patients, more quickly.

Sophie Bailes
Director Digital Transformation
CPI helped us accelerate a vital aspect of our manufacturing process to expedite our journey towards a clinical product. We’ve made significant progress in our GMP manufacturing capabilities, leading to our first DNA sales and increased interest in our products from partners and client base.

Carmen Mañas Torres
Team Leader in Synthetic DNA Purification
Manufacturing is just one part of the process, and CPI does so much more than just that. Growing mycolicibacteria consistently and reliably to food grade standard and combining them with other ingredients is difficult and requires attention to detail, expertise and experience from your partner.

Tim Dye
Senior Scientific and Operations Advisor
Trusted by leading organisations
CPI was an excellent partner, aiding in demonstrating the manufacturing feasibility of our top bacterial candidates and distinguishing between strains in co-cultures. Their facilities in Darlington were impressive, facilitating rapid data generation. We’re now collaborating with CPI again to complete our preclinical program and prepare for the launch of our symbiotic supplement. I am excited to see this hard work translate into improved health for the next generation of infants!

Lydia Mapstone
CEO
With CPI, we’ve shown that ambient-stable vaccine formulations are achievable, enabling global vaccine equity. CPI’s expertise, including proving the large-scale manufacturability of our TheraPHIX™ stabiliser, has advanced us far faster than we could have managed alone, giving us the credibility to aim for widespread adoption by vaccine manufacturers worldwide.

Andrew Goldsborough
CEO
Thanks to the expertise in drug development and manufacture brought by the colleagues from Quay, CPI and Pharmidex, we successfully developed a scalable manufacturing process for oral antibody products.

Silvia Matiz
Formulation Scientist
With digital tools we can build in operational excellence right from the start of pharmaceutical development, improve product robustness, and drive more efficient manufacturing processes to deliver more medicines to more patients, more quickly.

Sophie Bailes
Director Digital Transformation
CPI helped us accelerate a vital aspect of our manufacturing process to expedite our journey towards a clinical product. We’ve made significant progress in our GMP manufacturing capabilities, leading to our first DNA sales and increased interest in our products from partners and client base.

Carmen Mañas Torres
Team Leader in Synthetic DNA Purification
Manufacturing is just one part of the process, and CPI does so much more than just that. Growing mycolicibacteria consistently and reliably to food grade standard and combining them with other ingredients is difficult and requires attention to detail, expertise and experience from your partner.

Tim Dye
Senior Scientific and Operations Advisor
Why choose CPI?
Why choose CPI?
Work with us to defer capital and workforce investments until your product or process is proven at scale.






















