Oligonucleotides

Optimising the development and scale-up of oligonucleotide-based therapeutics.

Get to market faster with CPI

At CPI, we accelerate the development, optimisation, and scale-up of oligonucleotide therapies, enabling efficient and cost effective production of antisense oligonucleotides (ASOs), small interfering RNA (siRNA), oligo-conjugates through standard and new approaches including hybrid fragment synthesis and new synthesis methodologies.

With expertise in synthesis, purification, formulation, and analytical characterisation, we help you streamline oligonucleotide manufacturing while ensuring stability, scalability, and clinical readiness. Our state-of-the-art infrastructure and GMP-ready facilities support preclinical and clinical development, helping you bring next-generation therapies to market faster.

Three circular particles with a blue core.

Oligonucleotides

Optimising the development and scale-up of oligonucleotide-based therapeutics.

Get to market faster with CPI

At CPI, we accelerate the development, optimisation, and scale-up of oligonucleotide therapies, enabling efficient and cost effective production of antisense oligonucleotides (ASOs), small interfering RNA (siRNA), oligo-conjugates through standard and new approaches including hybrid fragment synthesis and new synthesis methodologies.

With expertise in synthesis, purification, formulation, and analytical characterisation, we help you streamline oligonucleotide manufacturing while ensuring stability, scalability, and clinical readiness. Our state-of-the-art infrastructure and GMP-ready facilities support preclinical and clinical development, helping you bring next-generation therapies to market faster.

Three circular particles with a blue core.

Oligonucleotides

Optimising the development and scale-up of oligonucleotide-based therapeutics.

Get to market faster with CPI

At CPI, we accelerate the development, optimisation, and scale-up of oligonucleotide therapies, enabling efficient and cost effective production of antisense oligonucleotides (ASOs), small interfering RNA (siRNA), oligo-conjugates through standard and new approaches including hybrid fragment synthesis and new synthesis methodologies.

With expertise in synthesis, purification, formulation, and analytical characterisation, we help you streamline oligonucleotide manufacturing while ensuring stability, scalability, and clinical readiness. Our state-of-the-art infrastructure and GMP-ready facilities support preclinical and clinical development, helping you bring next-generation therapies to market faster.

  • SGS Quay Pharma
  • BoobyBiome
  • RNAssist
  • Intract Pharma
  • Pharmidex
  • AstraZeneca

What we offer

Whether you need technical expertise, lab-based development, process optimisation, or regulatory guidance, our tailored approach ensures you have the right support at every stage.

What we offer

Whether you need technical expertise, lab-based development, process optimisation, or regulatory guidance, our tailored approach ensures you have the right support at every stage.

What we offer

Whether you need technical expertise, lab-based development, process optimisation, or regulatory guidance, our tailored approach ensures you have the right support at every stage.

Oligonucleotide process development and scale-up

Optimise and scale your oligonucleotide therapeutics with CPI’s expertise: 

  • Synthesis of ASOs, siRNA and oligo-conjugates. 

  • Optimisation of reaction conditions for enhanced yield and purity.

  • Enzymatic and chemical oligonucleotide synthesis technologies.

  • Downstream purification via anion exchange chromatography and ultrafiltration.

  • Techno-economic evaluation of novel synthesis and purification strategies.

  • Process development from milligram to gram-scale.

  • Process equipment including Cytiva’s OligoSynt™, Äkta Flux™, and  Äkta Pure™.

These capabilities ensure cost-effective, scalable oligonucleotide manufacturing.

Oligonucleotide process development and scale-up

Optimise and scale your oligonucleotide therapeutics with CPI’s expertise: 

  • Synthesis of ASOs, siRNA and oligo-conjugates. 

  • Optimisation of reaction conditions for enhanced yield and purity.

  • Enzymatic and chemical oligonucleotide synthesis technologies.

  • Downstream purification via anion exchange chromatography and ultrafiltration.

  • Techno-economic evaluation of novel synthesis and purification strategies.

  • Process development from milligram to gram-scale.

  • Process equipment including Cytiva’s OligoSynt™, Äkta Flux™, and  Äkta Pure™.

These capabilities ensure cost-effective, scalable oligonucleotide manufacturing.

Oligonucleotide analytical development and characterisation

Ensure the quality, integrity, and stability of your oligonucleotide-based therapeutics with CPI’s analytical expertise:

  • Purity analysis in our on-site QC lab with high resolution LC-MS.

  • LC-MS method development and validation.

  • Thermo Fisher Scientific Vanquish HPLC coupled to Exploris 120 or ISQ mass spectrometers for accurate molecular weight, purity and sequence information.

  • Additional test methods including UV-Vis spectrometer, Raman, GC and Endotoxin analysis.

  • Method development validation.

  • Supporting information for regulatory submissions. 

These capabilities ensure compliance with stringent quality and regulatory standards.

Oligonucleotide analytical development and characterisation

Ensure the quality, integrity, and stability of your oligonucleotide-based therapeutics with CPI’s analytical expertise:

  • Purity analysis in our on-site QC lab with high resolution LC-MS.

  • LC-MS method development and validation.

  • Thermo Fisher Scientific Vanquish HPLC coupled to Exploris 120 or ISQ mass spectrometers for accurate molecular weight, purity and sequence information.

  • Additional test methods including UV-Vis spectrometer, Raman, GC and Endotoxin analysis.

  • Method development validation.

  • Supporting information for regulatory submissions. 

These capabilities ensure compliance with stringent quality and regulatory standards.

GMP supply for preclinical and clinical studies

Secure high-quality oligonucleotides for early-stage development:

  • Scalable oligonucleotide production for gram scale (1–30 mmol) for pre-clinical studies.

  • Clinical-grade oligonucleotide synthesis at kg scale (10–150 mmol).

  • Cytiva’s OligoPilot™, Äktaprocess™ and Uniflux™ with supporting process equipment.

  • Electronic batch record and dedicated process transfer support.

  • Seamless integration with supply chain partners for formulation development and drug product manufacturing.

  • Evaluation and integration of new process technologies, including biocatalytic, liquid phase and fragment-based synthesis.

  • Full package of quality assurance services, including ‘Qualified Person’.

These capabilities support regulatory compliance and enable smooth progression from discovery to clinical trials.

GMP supply for preclinical and clinical studies

Secure high-quality oligonucleotides for early-stage development:

  • Scalable oligonucleotide production for gram scale (1–30 mmol) for pre-clinical studies.

  • Clinical-grade oligonucleotide synthesis at kg scale (10–150 mmol).

  • Cytiva’s OligoPilot™, Äktaprocess™ and Uniflux™ with supporting process equipment.

  • Electronic batch record and dedicated process transfer support.

  • Seamless integration with supply chain partners for formulation development and drug product manufacturing.

  • Evaluation and integration of new process technologies, including biocatalytic, liquid phase and fragment-based synthesis.

  • Full package of quality assurance services, including ‘Qualified Person’.

These capabilities support regulatory compliance and enable smooth progression from discovery to clinical trials.

Oligonucleotides applications

We enable innovation across a wide range of oligonucleotide and RNA therapeutics, including gene silencing and modulation treatments.

Scientist in a mask and safety glasses holding up a small clear glass vial.

Oligonucleotides applications

We enable innovation across a wide range of oligonucleotide and RNA therapeutics, including gene silencing and modulation treatments.

Scientist in a mask and safety glasses holding up a small clear glass vial.

Oligonucleotides applications

We enable innovation across a wide range of oligonucleotide and RNA therapeutics, including gene silencing and modulation treatments.

Scientist in a mask and safety glasses holding up a small clear glass vial.

How we support you

From discovery to commercialisation, we enable scalable, cost-effective, and regulatory-compliant pharmaceutical innovations.

How we support you

From discovery to commercialisation, we enable scalable, cost-effective, and regulatory-compliant pharmaceutical innovations.

How we support you

From discovery to commercialisation, we enable scalable, cost-effective, and regulatory-compliant pharmaceutical innovations.

Demonstrate the benefits of your oligonucleotide innovation

Leverage our expertise to accelerate early-stage development and build investor confidence with:

  • Fast, cost-effective oligonucleotide process development to support funding and investment.

  • Demonstration of oligonucleotide processes in industry-relevant settings.

Demonstrate the benefits of your oligonucleotide innovation

Leverage our expertise to accelerate early-stage development and build investor confidence with:

  • Fast, cost-effective oligonucleotide process development to support funding and investment.

  • Demonstration of oligonucleotide processes in industry-relevant settings.

Prove manufacturability and scalability

Ensure your oligonucleotide therapies are reproducible and scalable with our advanced processing expertise. With CPI, you can access:

  • Early-stage manufacturability assessments for oligonucleotide production.

  • Process optimisation for yield, stability, and cost-effectiveness.

  • Scalable synthesis and purification methods for clinical readiness.

Prove manufacturability and scalability

Ensure your oligonucleotide therapies are reproducible and scalable with our advanced processing expertise. With CPI, you can access:

  • Early-stage manufacturability assessments for oligonucleotide production.

  • Process optimisation for yield, stability, and cost-effectiveness.

  • Scalable synthesis and purification methods for clinical readiness.

Assess and demonstrate commercial viability

We provide data-driven insights and process validation to secure investment and commercial partnerships. We support with: 

  • Commercial feasibility assessments for oligonucleotide-based therapeutics.

  • Industrialisation of scale-up processes to secure funding or licensing deals.

  • Transitioning from preclinical development to commercial production.

Assess and demonstrate commercial viability

We provide data-driven insights and process validation to secure investment and commercial partnerships. We support with: 

  • Commercial feasibility assessments for oligonucleotide-based therapeutics.

  • Industrialisation of scale-up processes to secure funding or licensing deals.

  • Transitioning from preclinical development to commercial production.

Secure strategic partnerships

As a trusted UK government partner, we have built a broad network across global leaders, emerging companies, large corporates, healthcare, and academia. We help you to:

  • Access our network of world-class technology providers, academic partners, and support for regulatory, raw material supply chain and downstream formulation partners.

  • Build robust supply chains for oligonucleotide drug production.

  • Collaborate on industry-wide oligonucleotide innovation challenges.

Secure strategic partnerships

As a trusted UK government partner, we have built a broad network across global leaders, emerging companies, large corporates, healthcare, and academia. We help you to:

  • Access our network of world-class technology providers, academic partners, and support for regulatory, raw material supply chain and downstream formulation partners.

  • Build robust supply chains for oligonucleotide drug production.

  • Collaborate on industry-wide oligonucleotide innovation challenges.

  • Stainless steel process equipment skid installed in a pharmaceutical cleanroom.
    White oval tablets in the tray of a pharmaceutical counting and inspection machine.
  • Gowned scientist using a pipette to transfer a sample into a tube inside a laminar flow hood.
    CPI scientist in a lab coat and safety glasses using a pipette at a laboratory bench.
  • CPI scientist in a blue lab coat operating an ambr 250 automated bioreactor system with a tablet.
  • Row of capped glass vials moving along a pharmaceutical filling line.
    CPI scientist in safety glasses using a pipette to handle a pink sample in a laboratory.
  • CPI scientist drawing a process diagram on a glass screen in a laboratory.
    CPI scientists in blue lab coats operating analytical equipment in a laboratory.
  • Gloved hand placing a strip of PCR tubes containing blue liquid into a thermal cycler.
  • Stainless steel process equipment skid installed in a pharmaceutical cleanroom.
    White oval tablets in the tray of a pharmaceutical counting and inspection machine.
  • Gowned scientist using a pipette to transfer a sample into a tube inside a laminar flow hood.
    CPI scientist in a lab coat and safety glasses using a pipette at a laboratory bench.
  • CPI scientist in a blue lab coat operating an ambr 250 automated bioreactor system with a tablet.
  • Row of capped glass vials moving along a pharmaceutical filling line.
    CPI scientist in safety glasses using a pipette to handle a pink sample in a laboratory.
  • CPI scientist drawing a process diagram on a glass screen in a laboratory.
    CPI scientists in blue lab coats operating analytical equipment in a laboratory.
  • Gloved hand placing a strip of PCR tubes containing blue liquid into a thermal cycler.
  • Stainless steel process equipment skid installed in a pharmaceutical cleanroom.
    White oval tablets in the tray of a pharmaceutical counting and inspection machine.
  • Gowned scientist using a pipette to transfer a sample into a tube inside a laminar flow hood.
    CPI scientist in a lab coat and safety glasses using a pipette at a laboratory bench.
  • CPI scientist in a blue lab coat operating an ambr 250 automated bioreactor system with a tablet.
  • Row of capped glass vials moving along a pharmaceutical filling line.
    CPI scientist in safety glasses using a pipette to handle a pink sample in a laboratory.
  • CPI scientist drawing a process diagram on a glass screen in a laboratory.
    CPI scientists in blue lab coats operating analytical equipment in a laboratory.
  • Gloved hand placing a strip of PCR tubes containing blue liquid into a thermal cycler.
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Trusted by leading organisations

Showing slide 1 of 1
BoobyBiome

CPI was an excellent partner, aiding in demonstrating the manufacturing feasibility of our top bacterial candidates and distinguishing between strains in co-cultures. Their facilities in Darlington were impressive, facilitating rapid data generation. We’re now collaborating with CPI again to complete our preclinical program and prepare for the launch of our symbiotic supplement. I am excited to see this hard work translate into improved health for the next generation of infants!

Headshot of Lydia Mapstone, CEO

Lydia Mapstone

CEO

RNAssist

With CPI, we’ve shown that ambient-stable vaccine formulations are achievable, enabling global vaccine equity. CPI’s expertise, including proving the large-scale manufacturability of our TheraPHIX™ stabiliser, has advanced us far faster than we could have managed alone, giving us the credibility to aim for widespread adoption by vaccine manufacturers worldwide.

Headshot of Andrew Goldsborough, CEO

Andrew Goldsborough

CEO

Intract Pharma

Thanks to the expertise in drug development and manufacture brought by the colleagues from Quay, CPI and Pharmidex, we successfully developed a scalable manufacturing process for oral antibody products.

Headshot of Silvia Matiz, Formulation Scientist

Silvia Matiz

Formulation Scientist

AstraZeneca

With digital tools we can build in operational excellence right from the start of pharmaceutical development, improve product robustness, and drive more efficient manufacturing processes to deliver more medicines to more patients, more quickly.

Headshot of Sophie Bailes, Director Digital Transformation

Sophie Bailes

Director Digital Transformation

4basebio

CPI helped us accelerate a vital aspect of our manufacturing process to expedite our journey towards a clinical product. We’ve made significant progress in our GMP manufacturing capabilities, leading to our first DNA sales and increased interest in our products from partners and client base.

Headshot of Carmen Mañas Torres, Team Leader in Synthetic DNA Purification

Carmen Mañas Torres

Team Leader in Synthetic DNA Purification

Immune Boost Clinic

Manufacturing is just one part of the process, and CPI does so much more than just that. Growing mycolicibacteria consistently and reliably to food grade standard and combining them with other ingredients is difficult and requires attention to detail, expertise and experience from your partner.

Headshot of Tim Dye, Senior Scientific and Operations Advisor

Tim Dye

Senior Scientific and Operations Advisor

Trusted by leading organisations

Showing slide 1 of 1
BoobyBiome

CPI was an excellent partner, aiding in demonstrating the manufacturing feasibility of our top bacterial candidates and distinguishing between strains in co-cultures. Their facilities in Darlington were impressive, facilitating rapid data generation. We’re now collaborating with CPI again to complete our preclinical program and prepare for the launch of our symbiotic supplement. I am excited to see this hard work translate into improved health for the next generation of infants!

Headshot of Lydia Mapstone, CEO

Lydia Mapstone

CEO

RNAssist

With CPI, we’ve shown that ambient-stable vaccine formulations are achievable, enabling global vaccine equity. CPI’s expertise, including proving the large-scale manufacturability of our TheraPHIX™ stabiliser, has advanced us far faster than we could have managed alone, giving us the credibility to aim for widespread adoption by vaccine manufacturers worldwide.

Headshot of Andrew Goldsborough, CEO

Andrew Goldsborough

CEO

Intract Pharma

Thanks to the expertise in drug development and manufacture brought by the colleagues from Quay, CPI and Pharmidex, we successfully developed a scalable manufacturing process for oral antibody products.

Headshot of Silvia Matiz, Formulation Scientist

Silvia Matiz

Formulation Scientist

AstraZeneca

With digital tools we can build in operational excellence right from the start of pharmaceutical development, improve product robustness, and drive more efficient manufacturing processes to deliver more medicines to more patients, more quickly.

Headshot of Sophie Bailes, Director Digital Transformation

Sophie Bailes

Director Digital Transformation

4basebio

CPI helped us accelerate a vital aspect of our manufacturing process to expedite our journey towards a clinical product. We’ve made significant progress in our GMP manufacturing capabilities, leading to our first DNA sales and increased interest in our products from partners and client base.

Headshot of Carmen Mañas Torres, Team Leader in Synthetic DNA Purification

Carmen Mañas Torres

Team Leader in Synthetic DNA Purification

Immune Boost Clinic

Manufacturing is just one part of the process, and CPI does so much more than just that. Growing mycolicibacteria consistently and reliably to food grade standard and combining them with other ingredients is difficult and requires attention to detail, expertise and experience from your partner.

Headshot of Tim Dye, Senior Scientific and Operations Advisor

Tim Dye

Senior Scientific and Operations Advisor

Trusted by leading organisations

Showing slide 1 of 1
BoobyBiome

CPI was an excellent partner, aiding in demonstrating the manufacturing feasibility of our top bacterial candidates and distinguishing between strains in co-cultures. Their facilities in Darlington were impressive, facilitating rapid data generation. We’re now collaborating with CPI again to complete our preclinical program and prepare for the launch of our symbiotic supplement. I am excited to see this hard work translate into improved health for the next generation of infants!

Headshot of Lydia Mapstone, CEO

Lydia Mapstone

CEO

RNAssist

With CPI, we’ve shown that ambient-stable vaccine formulations are achievable, enabling global vaccine equity. CPI’s expertise, including proving the large-scale manufacturability of our TheraPHIX™ stabiliser, has advanced us far faster than we could have managed alone, giving us the credibility to aim for widespread adoption by vaccine manufacturers worldwide.

Headshot of Andrew Goldsborough, CEO

Andrew Goldsborough

CEO

Intract Pharma

Thanks to the expertise in drug development and manufacture brought by the colleagues from Quay, CPI and Pharmidex, we successfully developed a scalable manufacturing process for oral antibody products.

Headshot of Silvia Matiz, Formulation Scientist

Silvia Matiz

Formulation Scientist

AstraZeneca

With digital tools we can build in operational excellence right from the start of pharmaceutical development, improve product robustness, and drive more efficient manufacturing processes to deliver more medicines to more patients, more quickly.

Headshot of Sophie Bailes, Director Digital Transformation

Sophie Bailes

Director Digital Transformation

4basebio

CPI helped us accelerate a vital aspect of our manufacturing process to expedite our journey towards a clinical product. We’ve made significant progress in our GMP manufacturing capabilities, leading to our first DNA sales and increased interest in our products from partners and client base.

Headshot of Carmen Mañas Torres, Team Leader in Synthetic DNA Purification

Carmen Mañas Torres

Team Leader in Synthetic DNA Purification

Immune Boost Clinic

Manufacturing is just one part of the process, and CPI does so much more than just that. Growing mycolicibacteria consistently and reliably to food grade standard and combining them with other ingredients is difficult and requires attention to detail, expertise and experience from your partner.

Headshot of Tim Dye, Senior Scientific and Operations Advisor

Tim Dye

Senior Scientific and Operations Advisor

Get in touch

Get in touch

Get in touch