Bioprocess development and scale-up

Downstream processing

Expertise in isolating and purifying high-quality bioproducts for commercial success.

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From discovery to industrial scale

We understand the critical role downstream processing plays in the commercial success of biobased materials.

Our expert teams provide comprehensive downstream processing solutions, from initial product isolation through to final purification and formulation, enabling you to deliver high-quality bioproducts rapidly and cost-effectively.

Leveraging our extensive infrastructure and commercially focused expertise, we help you efficiently scale your bioprocesses, ensuring consistent quality and regulatory compliance. 

CPI expert operating equipment in a lab.

Bioprocess development and scale-up

Downstream processing

Expertise in isolating and purifying high-quality bioproducts for commercial success.

Get in touch

View capabilities

From discovery to industrial scale

We understand the critical role downstream processing plays in the commercial success of biobased materials.

Our expert teams provide comprehensive downstream processing solutions, from initial product isolation through to final purification and formulation, enabling you to deliver high-quality bioproducts rapidly and cost-effectively.

Leveraging our extensive infrastructure and commercially focused expertise, we help you efficiently scale your bioprocesses, ensuring consistent quality and regulatory compliance. 

CPI expert operating equipment in a lab.

Bioprocess development and scale-up

Downstream processing

Expertise in isolating and purifying high-quality bioproducts for commercial success.

Get in touch

View capabilities

From discovery to industrial scale

We understand the critical role downstream processing plays in the commercial success of biobased materials.

Our expert teams provide comprehensive downstream processing solutions, from initial product isolation through to final purification and formulation, enabling you to deliver high-quality bioproducts rapidly and cost-effectively.

Leveraging our extensive infrastructure and commercially focused expertise, we help you efficiently scale your bioprocesses, ensuring consistent quality and regulatory compliance. 

  • Oxford Biotrans
  • Calysta
  • Azotic
  • 3D Bio-Tissues
  • Newcastle University
  • Immune Boost Clinic

What we offer

Our dedicated downstream processing team provides expertise in isolating and purifying bioproducts, from recombinant proteins to metabolites and fermentation biomass. Our advanced facilities and technologies ensure the highest standards of purity, yield, and performance across multiple scales.

What we offer

Our dedicated downstream processing team provides expertise in isolating and purifying bioproducts, from recombinant proteins to metabolites and fermentation biomass. Our advanced facilities and technologies ensure the highest standards of purity, yield, and performance across multiple scales.

What we offer

Our dedicated downstream processing team provides expertise in isolating and purifying bioproducts, from recombinant proteins to metabolites and fermentation biomass. Our advanced facilities and technologies ensure the highest standards of purity, yield, and performance across multiple scales.

Product isolation and recovery

Efficient recovery of your target bioproduct is crucial for commercial viability. We offer a range of tailored techniques to maximise product yield and purity: 

  • High-efficiency centrifugation for effective separation of biomass and product. 

  • Homogenisation processes to improve product recovery and downstream handling. 

  • Filtration technologies, including microfiltration, ultrafiltration, nanofiltration and reverse osmosis, tailored to your product specifications. 

  • Solvent extraction methods optimised for high product purity and yield. 

Product isolation and recovery

Efficient recovery of your target bioproduct is crucial for commercial viability. We offer a range of tailored techniques to maximise product yield and purity: 

  • High-efficiency centrifugation for effective separation of biomass and product. 

  • Homogenisation processes to improve product recovery and downstream handling. 

  • Filtration technologies, including microfiltration, ultrafiltration, nanofiltration and reverse osmosis, tailored to your product specifications. 

  • Solvent extraction methods optimised for high product purity and yield. 

Advanced purification techniques

Our purification methods deliver superior quality, ensuring your products consistently meet commercial and regulatory requirements: 

  • Affinity chromatography for selective purification of proteins and biomolecules. 

  • Ion-exchange chromatography to separate products based on charge. 

  • Size-exclusion chromatography for separation by molecular size. 

  • Precipitation and crystallisation techniques for product refinement and concentration. 

Advanced purification techniques

Our purification methods deliver superior quality, ensuring your products consistently meet commercial and regulatory requirements: 

  • Affinity chromatography for selective purification of proteins and biomolecules. 

  • Ion-exchange chromatography to separate products based on charge. 

  • Size-exclusion chromatography for separation by molecular size. 

  • Precipitation and crystallisation techniques for product refinement and concentration. 

Formulation development

We help optimise final product formulations to enhance stability, shelf-life, and performance, preparing your products effectively for market. 

  • Tailored formulation strategies for diverse market applications. 

  • Stability and shelf-life optimisation to ensure consistent product performance. 

  • Scalable drying processes including freeze-drying, spray drying, and fluidised bed drying. 

  • Lab-scale testing and pilot formulation trials for accelerated development. 

Formulation development

We help optimise final product formulations to enhance stability, shelf-life, and performance, preparing your products effectively for market. 

  • Tailored formulation strategies for diverse market applications. 

  • Stability and shelf-life optimisation to ensure consistent product performance. 

  • Scalable drying processes including freeze-drying, spray drying, and fluidised bed drying. 

  • Lab-scale testing and pilot formulation trials for accelerated development. 

Scale-up and validation

CPI’s specialised scale-up infrastructure and expertise facilitate the transition from laboratory-scale development to robust commercial production, minimising risk and optimising efficiency. 

  • Comprehensive scale-down lab models for accurate process predictions. 

  • Access to pilot and demonstration-scale facilities for industrially-relevant  process validation. 

  • Detailed techno-economic analyses and lifecycle assessments. 

Scale-up and validation

CPI’s specialised scale-up infrastructure and expertise facilitate the transition from laboratory-scale development to robust commercial production, minimising risk and optimising efficiency. 

  • Comprehensive scale-down lab models for accurate process predictions. 

  • Access to pilot and demonstration-scale facilities for industrially-relevant  process validation. 

  • Detailed techno-economic analyses and lifecycle assessments. 

Analytical and regulatory support

Our in-depth analytical capabilities and regulatory expertise streamline your path to commercialisation, ensuring full compliance and high product quality. 

  • Advanced analytical characterisation methods to verify product purity and consistency. 

  • Compliance support including GMP, HACCP, FDA, and other global regulatory standards. 

  • Data generation and regulatory dossier preparation for smooth market entry. 

Analytical and regulatory support

Our in-depth analytical capabilities and regulatory expertise streamline your path to commercialisation, ensuring full compliance and high product quality. 

  • Advanced analytical characterisation methods to verify product purity and consistency. 

  • Compliance support including GMP, HACCP, FDA, and other global regulatory standards. 

  • Data generation and regulatory dossier preparation for smooth market entry. 

Can’t find what you’re looking for?

With over 500 experts we are here to help.

Get in touch

Can’t find what you’re looking for?

With over 500 experts we are here to help.

Get in touch

Can’t find what you’re looking for?

With over 500 experts we are here to help.

Get in touch

Downstream processing applications

We support downstream processing across diverse applications to enhance product purity, quality, and commercial viability.

Therapeutic proteins and peptides.

Sustainable chemicals and materials.

Nutraceuticals.

Alternative proteins.

Cosmetic and personal care ingredients.

Food and beverage ingredients.

Home care and cleaning solutions.

Bio-based monomers and polymer.

Eight-channel pipette with orange tips positioned over a blue microplate in a laboratory.

Downstream processing applications

We support downstream processing across diverse applications to enhance product purity, quality, and commercial viability.

Therapeutic proteins and peptides.

Sustainable chemicals and materials.

Nutraceuticals.

Alternative proteins.

Cosmetic and personal care ingredients.

Food and beverage ingredients.

Home care and cleaning solutions.

Bio-based monomers and polymer.

Eight-channel pipette with orange tips positioned over a blue microplate in a laboratory.

Downstream processing applications

We support downstream processing across diverse applications to enhance product purity, quality, and commercial viability.

Therapeutic proteins and peptides.

Sustainable chemicals and materials.

Nutraceuticals.

Alternative proteins.

Cosmetic and personal care ingredients.

Food and beverage ingredients.

Home care and cleaning solutions.

Bio-based monomers and polymer.

Eight-channel pipette with orange tips positioned over a blue microplate in a laboratory.

How we support you

Our specialised infrastructure, dedicated scientists, and commercially focused approach ensure a smooth transition from laboratory-scale development to market-ready bioproducts.

How we support you

Our specialised infrastructure, dedicated scientists, and commercially focused approach ensure a smooth transition from laboratory-scale development to market-ready bioproducts.

How we support you

Our specialised infrastructure, dedicated scientists, and commercially focused approach ensure a smooth transition from laboratory-scale development to market-ready bioproducts.

Optimise and de-risk your downstream processes 

We guide you through the complexities of downstream processing, optimising yield, purity, and cost-effectiveness. Our team ensures scalable, reproducible processes tailored specifically to your bioproduct requirements, from recombinant proteins and metabolites to biomass and bio-based chemicals. 

Optimise and de-risk your downstream processes 

We guide you through the complexities of downstream processing, optimising yield, purity, and cost-effectiveness. Our team ensures scalable, reproducible processes tailored specifically to your bioproduct requirements, from recombinant proteins and metabolites to biomass and bio-based chemicals. 

Scale with confidence 

Transitioning from laboratory scale to commercial production involves substantial risk. We offer access to pilot and demonstration-scale facilities, helping you validate and refine your downstream processes before significant capital investment. Our comprehensive techno-economic assessments and validation protocols facilitate seamless scaling, ensuring successful commercial production. 

Scale with confidence 

Transitioning from laboratory scale to commercial production involves substantial risk. We offer access to pilot and demonstration-scale facilities, helping you validate and refine your downstream processes before significant capital investment. Our comprehensive techno-economic assessments and validation protocols facilitate seamless scaling, ensuring successful commercial production. 

Intellectual property development and protection

We support you in developing and protecting your IP, providing secure environments and expert guidance. By collaborating closely with you, we help develop proprietary downstream processing technologies that maintain your competitive edge. 

Intellectual property development and protection

We support you in developing and protecting your IP, providing secure environments and expert guidance. By collaborating closely with you, we help develop proprietary downstream processing technologies that maintain your competitive edge. 

Navigate regulatory and commercial hurdles 

CPI’s specialised scale-up infrastructure and expertise facilitate the transition from laboratory-scale development to robust commercial production, minimising risk and optimising efficiency. 

  • Comprehensive scale-down lab models for accurate process predictions. 

  • Access to pilot and demonstration-scale facilities for industrially-relevant  process validation. 

  • Detailed techno-economic analyses and lifecycle assessments. 

Navigate regulatory and commercial hurdles 

CPI’s specialised scale-up infrastructure and expertise facilitate the transition from laboratory-scale development to robust commercial production, minimising risk and optimising efficiency. 

  • Comprehensive scale-down lab models for accurate process predictions. 

  • Access to pilot and demonstration-scale facilities for industrially-relevant  process validation. 

  • Detailed techno-economic analyses and lifecycle assessments. 

Facilitate investment and accelerate innovation 

Securing funding is crucial for scaling downstream processes. Our team assists you in obtaining public and private investment through strategic partnerships, grant applications, and funding opportunities. Collaborating with industry, academia, and government, we provide essential resources, market insights, and investment pathways to accelerate your downstream processing innovations. 

Facilitate investment and accelerate innovation 

Securing funding is crucial for scaling downstream processes. Our team assists you in obtaining public and private investment through strategic partnerships, grant applications, and funding opportunities. Collaborating with industry, academia, and government, we provide essential resources, market insights, and investment pathways to accelerate your downstream processing innovations. 

  • CPI scientist using a VWR pipette controller to fill a serological pipette in a laboratory.
    CPI operator at a GEA Ariete industrial homogeniser in a process facility.
  • Automated sampler probe dipping into a sample tube in a rack, with a CPI scientist watching behind.
    Stainless steel disc-stack centrifuge with a green motor, with an operator working in the background.
  • Stainless steel pilot process rig with looped pipework and a blue pump in a facility.
  • CPI scientist working at a HEL parallel automated reactor system behind a glass door.
    CPI scientist drawing a process diagram on a glass screen in a laboratory.
  • Gloved hands holding a petri dish with a bacterial streak culture while using an inoculation tool.
    CPI scientist using an Olympus microscope with the magnified sample shown on a monitor.
  • Gloved hand holding a petri dish with orange bacterial colonies streaked across the agar.
  • CPI scientist using a VWR pipette controller to fill a serological pipette in a laboratory.
    CPI operator at a GEA Ariete industrial homogeniser in a process facility.
  • Automated sampler probe dipping into a sample tube in a rack, with a CPI scientist watching behind.
    Stainless steel disc-stack centrifuge with a green motor, with an operator working in the background.
  • Stainless steel pilot process rig with looped pipework and a blue pump in a facility.
  • CPI scientist working at a HEL parallel automated reactor system behind a glass door.
    CPI scientist drawing a process diagram on a glass screen in a laboratory.
  • Gloved hands holding a petri dish with a bacterial streak culture while using an inoculation tool.
    CPI scientist using an Olympus microscope with the magnified sample shown on a monitor.
  • Gloved hand holding a petri dish with orange bacterial colonies streaked across the agar.
  • CPI scientist using a VWR pipette controller to fill a serological pipette in a laboratory.
    CPI operator at a GEA Ariete industrial homogeniser in a process facility.
  • Automated sampler probe dipping into a sample tube in a rack, with a CPI scientist watching behind.
    Stainless steel disc-stack centrifuge with a green motor, with an operator working in the background.
  • Stainless steel pilot process rig with looped pipework and a blue pump in a facility.
  • CPI scientist working at a HEL parallel automated reactor system behind a glass door.
    CPI scientist drawing a process diagram on a glass screen in a laboratory.
  • Gloved hands holding a petri dish with a bacterial streak culture while using an inoculation tool.
    CPI scientist using an Olympus microscope with the magnified sample shown on a monitor.
  • Gloved hand holding a petri dish with orange bacterial colonies streaked across the agar.
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Trusted by leading organisations

Showing slide 1 of 1
Oxford Biotrans

Our project with CPI was the springboard for our technology commercialisation programme and subsequent market launch. The CPI team were knowledgeable, approachable and responsive and proved invaluable in rapidly overcoming the complex challenges that developing any new process requires.

A headshot of Jason King. .

Jason King

CEO

Touchlight Genetics

CPI has skillsets and equipment that are not readily available anywhere else. By using CPI’s skills, we have saved many months of process development.

Headshot of Dr Jill Makin, CTO

Dr Jill Makin

CTO

Calysta

We chose Teesside as a preferred location due to the commercial attractiveness, technical skills and research and development expertise in the area.

Headshot of Alan Shaw, CEO

Alan Shaw

CEO

Trusted by leading organisations

Showing slide 1 of 1
Oxford Biotrans

Our project with CPI was the springboard for our technology commercialisation programme and subsequent market launch. The CPI team were knowledgeable, approachable and responsive and proved invaluable in rapidly overcoming the complex challenges that developing any new process requires.

A headshot of Jason King. .

Jason King

CEO

Touchlight Genetics

CPI has skillsets and equipment that are not readily available anywhere else. By using CPI’s skills, we have saved many months of process development.

Headshot of Dr Jill Makin, CTO

Dr Jill Makin

CTO

Calysta

We chose Teesside as a preferred location due to the commercial attractiveness, technical skills and research and development expertise in the area.

Headshot of Alan Shaw, CEO

Alan Shaw

CEO

Trusted by leading organisations

Showing slide 1 of 1
Oxford Biotrans

Our project with CPI was the springboard for our technology commercialisation programme and subsequent market launch. The CPI team were knowledgeable, approachable and responsive and proved invaluable in rapidly overcoming the complex challenges that developing any new process requires.

A headshot of Jason King. .

Jason King

CEO

Touchlight Genetics

CPI has skillsets and equipment that are not readily available anywhere else. By using CPI’s skills, we have saved many months of process development.

Headshot of Dr Jill Makin, CTO

Dr Jill Makin

CTO

Calysta

We chose Teesside as a preferred location due to the commercial attractiveness, technical skills and research and development expertise in the area.

Headshot of Alan Shaw, CEO

Alan Shaw

CEO

Why choose CPI?

Work with us to defer capital and workforce investments until your product or process is proven at scale.

Advanced purification techniques

Comprehensive solutions from centrifugation to chromatography.

Precision product recovery

Tailored methods ensuring optimal purity and performance.

Flexible scalability

Robust infrastructure from laboratory to demonstration scale.

Drying expertise

Custom drying solutions for enhanced product stability and shelf life.

Analytical excellence

In-depth characterisation supporting quality assurance and compliance.

Regulatory and IP protection

Detailed regulatory assistance and strong IP development support.

Why choose CPI?

Work with us to defer capital and workforce investments until your product or process is proven at scale.

Advanced purification techniques

Comprehensive solutions from centrifugation to chromatography.

Precision product recovery

Tailored methods ensuring optimal purity and performance.

Flexible scalability

Robust infrastructure from laboratory to demonstration scale.

Drying expertise

Custom drying solutions for enhanced product stability and shelf life.

Analytical excellence

In-depth characterisation supporting quality assurance and compliance.

Regulatory and IP protection

Detailed regulatory assistance and strong IP development support.

Why choose CPI?

Work with us to defer capital and workforce investments until your product or process is proven at scale.

Advanced purification techniques

Comprehensive solutions from centrifugation to chromatography.

Precision product recovery

Tailored methods ensuring optimal purity and performance.

Flexible scalability

Robust infrastructure from laboratory to demonstration scale.

Drying expertise

Custom drying solutions for enhanced product stability and shelf life.

Analytical excellence

In-depth characterisation supporting quality assurance and compliance.

Regulatory and IP protection

Detailed regulatory assistance and strong IP development support.

Get in touch

Get in touch

Get in touch

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