Bioprocess development and scale-up

Biocatalysis

Accelerating biocatalytic process development from discovery to commercialisation.

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View capabilities

From lab to industrial scale

At CPI, we empower innovators to unlock the full potential of enzymes in sustainable manufacturing. Our comprehensive biocatalysis services support the design, development, and scale-up of biocatalytic processes to improve efficiency, reduce environmental impact, and deliver commercial success. 

Gloved hands loading small sample vials into an autosampler tray of a laboratory analytical instrument.

Bioprocess development and scale-up

Biocatalysis

Accelerating biocatalytic process development from discovery to commercialisation.

Get in touch

View capabilities

From lab to industrial scale

At CPI, we empower innovators to unlock the full potential of enzymes in sustainable manufacturing. Our comprehensive biocatalysis services support the design, development, and scale-up of biocatalytic processes to improve efficiency, reduce environmental impact, and deliver commercial success. 

Gloved hands loading small sample vials into an autosampler tray of a laboratory analytical instrument.

Bioprocess development and scale-up

Biocatalysis

Accelerating biocatalytic process development from discovery to commercialisation.

Get in touch

View capabilities

From lab to industrial scale

At CPI, we empower innovators to unlock the full potential of enzymes in sustainable manufacturing. Our comprehensive biocatalysis services support the design, development, and scale-up of biocatalytic processes to improve efficiency, reduce environmental impact, and deliver commercial success. 

  • Oxford Biotrans
  • Calysta
  • Azotic
  • 3D Bio-Tissues
  • Newcastle University
  • Immune Boost Clinic

What we offer

Our expert team supports you with enzyme screening, reaction intensification, process engineering, and scale-up, delivering high-performing biocatalytic solutions with exceptional purity, yield, and consistency across multiple scales.

What we offer

Our expert team supports you with enzyme screening, reaction intensification, process engineering, and scale-up, delivering high-performing biocatalytic solutions with exceptional purity, yield, and consistency across multiple scales.

What we offer

Our expert team supports you with enzyme screening, reaction intensification, process engineering, and scale-up, delivering high-performing biocatalytic solutions with exceptional purity, yield, and consistency across multiple scales.

Target reaction selection

We support you in identifying the optimal biocatalytic route to your product, ensuring high selectivity, efficiency, and commercial viability from the outset. 

  • Support in selecting the most effective biotransformation (e.g. asymmetric synthesis vs. chiral resolution). 

  • Guidance on integrating enzymatic steps into your overall process or synthesis scheme. 

  • De-risking by early-stage evaluation of scalability and economic feasibility assessment. 

Target reaction selection

We support you in identifying the optimal biocatalytic route to your product, ensuring high selectivity, efficiency, and commercial viability from the outset. 

  • Support in selecting the most effective biotransformation (e.g. asymmetric synthesis vs. chiral resolution). 

  • Guidance on integrating enzymatic steps into your overall process or synthesis scheme. 

  • De-risking by early-stage evaluation of scalability and economic feasibility assessment. 

Biocatalyst identification and screening

We can help you find the right enzyme, whether off-the-shelf or custom-engineered, to meet your project’s performance and stability requirements. 

  • Extensive enzyme mining using CPI’s network of public databases and global suppliers. 

  • Access to enzyme engineering and screening services for bespoke enzyme development. 

  • Biocatalyst screening under process-relevant conditions using our parallelised reactor systems. 

Biocatalyst identification and screening

We can help you find the right enzyme, whether off-the-shelf or custom-engineered, to meet your project’s performance and stability requirements. 

  • Extensive enzyme mining using CPI’s network of public databases and global suppliers. 

  • Access to enzyme engineering and screening services for bespoke enzyme development. 

  • Biocatalyst screening under process-relevant conditions using our parallelised reactor systems. 

Enzyme production and optimisation

Our fermentation and downstream processing experts utilise their vast experience to support the scalable production and formulation of enzymes tailored to your process requirements. 

  • Fermentation process development (1 mL to 5 L) to optimise enzyme yields. 

  • Downstream process development to formulate enzymes for optimal reaction performance. 

  • Support for enzyme stabilisation and immobilisation on solid supports, improving reusability and cost-effectiveness. 

Enzyme production and optimisation

Our fermentation and downstream processing experts utilise their vast experience to support the scalable production and formulation of enzymes tailored to your process requirements. 

  • Fermentation process development (1 mL to 5 L) to optimise enzyme yields. 

  • Downstream process development to formulate enzymes for optimal reaction performance. 

  • Support for enzyme stabilisation and immobilisation on solid supports, improving reusability and cost-effectiveness. 

Reaction optimisation

We work with you to intensify enzymatic reactions by screening various reaction parameters, applying machine learning and data-driven optimisations to minimise experimental efforts. 

  • Micro-scale reaction optimisation using parallelised reactors to identify optimal parameters.  

  • Control of stirring, temperature, pH, and reagent addition at lab-scale to simulate scalable process conditions. 

Reaction optimisation

We work with you to intensify enzymatic reactions by screening various reaction parameters, applying machine learning and data-driven optimisations to minimise experimental efforts. 

  • Micro-scale reaction optimisation using parallelised reactors to identify optimal parameters.  

  • Control of stirring, temperature, pH, and reagent addition at lab-scale to simulate scalable process conditions. 

Scale-up and validation

CPI’s specialised scale-up infrastructure and expertise facilitate the transition from laboratory-scale development to robust commercial production, minimising risk and optimising efficiency.  

  • Comprehensive scale-down lab models for accurate process predictions.  

  • Access to pilot and demonstration-scale facilities for industrially relevant process validation.  

  • Detailed techno-economic analyses and lifecycle assessments.  

Scale-up and validation

CPI’s specialised scale-up infrastructure and expertise facilitate the transition from laboratory-scale development to robust commercial production, minimising risk and optimising efficiency.  

  • Comprehensive scale-down lab models for accurate process predictions.  

  • Access to pilot and demonstration-scale facilities for industrially relevant process validation.  

  • Detailed techno-economic analyses and lifecycle assessments.  

Analytical and regulatory support 

Our in-depth analytical capabilities and regulatory expertise streamline your path to commercialisation, ensuring full compliance and high product quality.  

  • Advanced analytical characterisation methods to verify product purity and consistency.  Compliance support including GMP, HACCP, FDA, and other global regulatory standards.  

  • Data generation and regulatory dossier preparation for smooth market entry.  

Analytical and regulatory support 

Our in-depth analytical capabilities and regulatory expertise streamline your path to commercialisation, ensuring full compliance and high product quality.  

  • Advanced analytical characterisation methods to verify product purity and consistency.  Compliance support including GMP, HACCP, FDA, and other global regulatory standards.  

  • Data generation and regulatory dossier preparation for smooth market entry.  

Can’t find what you’re looking for?

With over 500 experts we are here to help.

Get in touch

Can’t find what you’re looking for?

With over 500 experts we are here to help.

Get in touch

Can’t find what you’re looking for?

With over 500 experts we are here to help.

Get in touch

Biocatalysis applications

Enzyme-driven innovation for scalable bioprocesses, including:

Speciality and fine chemicals.

Pharmaceutical intermediates.

Nutraceuticals and food ingredients.

Personal care and cosmetics.

Agrochemicals and biopesticides.

Sustainable chemicals.

Gloved hand holding a blue-tinted diagnostic test cassette while a probe dispenses liquid.

Biocatalysis applications

Enzyme-driven innovation for scalable bioprocesses, including:

Speciality and fine chemicals.

Pharmaceutical intermediates.

Nutraceuticals and food ingredients.

Personal care and cosmetics.

Agrochemicals and biopesticides.

Sustainable chemicals.

Gloved hand holding a blue-tinted diagnostic test cassette while a probe dispenses liquid.

Biocatalysis applications

Enzyme-driven innovation for scalable bioprocesses, including:

Speciality and fine chemicals.

Pharmaceutical intermediates.

Nutraceuticals and food ingredients.

Personal care and cosmetics.

Agrochemicals and biopesticides.

Sustainable chemicals.

Gloved hand holding a blue-tinted diagnostic test cassette while a probe dispenses liquid.

How we support you

At CPI, we provide end-to-end support to help you develop, optimise, and scale biocatalytic processes. Our expert teams and integrated infrastructure enable you to identify the right enzyme, streamline your reaction conditions, and accelerate commercialisation with confidence.

How we support you

At CPI, we provide end-to-end support to help you develop, optimise, and scale biocatalytic processes. Our expert teams and integrated infrastructure enable you to identify the right enzyme, streamline your reaction conditions, and accelerate commercialisation with confidence.

How we support you

At CPI, we provide end-to-end support to help you develop, optimise, and scale biocatalytic processes. Our expert teams and integrated infrastructure enable you to identify the right enzyme, streamline your reaction conditions, and accelerate commercialisation with confidence.

Optimise and de-risk your biocatalytic processes

We help you overcome the challenges of developing enzymatic pathways, ensuring high selectivity, stability, and scalability. From early reaction planning to late-stage process refinement, we support the development of robust and commercially viable biocatalytic solutions. 

Optimise and de-risk your biocatalytic processes

We help you overcome the challenges of developing enzymatic pathways, ensuring high selectivity, stability, and scalability. From early reaction planning to late-stage process refinement, we support the development of robust and commercially viable biocatalytic solutions. 

Scale up biocatalysis with confidence

Scaling biocatalytic processes requires seamless integration of enzyme production, formulation, and reaction control. Our infrastructure and expertise enable you to validate and optimise each step, supporting efficient scale-up to industrial production.

Scale up biocatalysis with confidence

Scaling biocatalytic processes requires seamless integration of enzyme production, formulation, and reaction control. Our infrastructure and expertise enable you to validate and optimise each step, supporting efficient scale-up to industrial production.

Develop and protect your IP

We provide a secure innovation environment where you retain ownership of your intellectual property. Our teams work closely with you to design proprietary biocatalytic processes, ensuring your innovations remain protected and competitive.

Develop and protect your IP

We provide a secure innovation environment where you retain ownership of your intellectual property. Our teams work closely with you to design proprietary biocatalytic processes, ensuring your innovations remain protected and competitive.

Navigate regulatory requirements efficiently

We work with you to intensify enzymatic reactions by screening various reaction parameters, applying machine learning and data-driven optimisations to minimise experimental efforts. 

  • Micro-scale reaction optimisation using parallelised reactors to identify optimal parameters.  

  • Control of stirring, temperature, pH, and reagent addition at lab-scale to simulate scalable process conditions. 

Navigate regulatory requirements efficiently

We work with you to intensify enzymatic reactions by screening various reaction parameters, applying machine learning and data-driven optimisations to minimise experimental efforts. 

  • Micro-scale reaction optimisation using parallelised reactors to identify optimal parameters.  

  • Control of stirring, temperature, pH, and reagent addition at lab-scale to simulate scalable process conditions. 

Secure funding and drive innovation

We help you access both public and private funding through strategic guidance on grants, investment rounds, and partner introductions. Our established network accelerates your journey from proof-of-concept to commercial success.

Secure funding and drive innovation

We help you access both public and private funding through strategic guidance on grants, investment rounds, and partner introductions. Our established network accelerates your journey from proof-of-concept to commercial success.

Leverage a full-service ecosystem

With integrated enzyme screening, fermentation, downstream processing, and formulation expertise under one roof, we offer a connected ecosystem that shortens development timelines and improves biocatalytic performance.

Leverage a full-service ecosystem

With integrated enzyme screening, fermentation, downstream processing, and formulation expertise under one roof, we offer a connected ecosystem that shortens development timelines and improves biocatalytic performance.

  • CPI scientist using a VWR pipette controller to fill a serological pipette in a laboratory.
    Gloved scientist using a pipette to fill blue microplates at a laboratory bench.
  • Automated sampler probe dipping into a sample tube in a rack, with a CPI scientist watching behind.
    CPI scientist operating an ambr 250 automated bioreactor system with a tablet.
  • Stainless steel pilot process rig with looped pipework and a blue pump in a facility.
  • CPI scientist working at a HEL parallel automated reactor system behind a glass door.
    CPI scientist drawing a process diagram on a glass screen in a laboratory.
  • Gloved hands holding a petri dish with a bacterial streak culture while using an inoculation tool.
    CPI scientist using an Olympus microscope with the magnified sample shown on a monitor.
  • Gloved hand holding a petri dish with orange bacterial colonies streaked across the agar.
  • CPI scientist using a VWR pipette controller to fill a serological pipette in a laboratory.
    Gloved scientist using a pipette to fill blue microplates at a laboratory bench.
  • Automated sampler probe dipping into a sample tube in a rack, with a CPI scientist watching behind.
    CPI scientist operating an ambr 250 automated bioreactor system with a tablet.
  • Stainless steel pilot process rig with looped pipework and a blue pump in a facility.
  • CPI scientist working at a HEL parallel automated reactor system behind a glass door.
    CPI scientist drawing a process diagram on a glass screen in a laboratory.
  • Gloved hands holding a petri dish with a bacterial streak culture while using an inoculation tool.
    CPI scientist using an Olympus microscope with the magnified sample shown on a monitor.
  • Gloved hand holding a petri dish with orange bacterial colonies streaked across the agar.
  • CPI scientist using a VWR pipette controller to fill a serological pipette in a laboratory.
    Gloved scientist using a pipette to fill blue microplates at a laboratory bench.
  • Automated sampler probe dipping into a sample tube in a rack, with a CPI scientist watching behind.
    CPI scientist operating an ambr 250 automated bioreactor system with a tablet.
  • Stainless steel pilot process rig with looped pipework and a blue pump in a facility.
  • CPI scientist working at a HEL parallel automated reactor system behind a glass door.
    CPI scientist drawing a process diagram on a glass screen in a laboratory.
  • Gloved hands holding a petri dish with a bacterial streak culture while using an inoculation tool.
    CPI scientist using an Olympus microscope with the magnified sample shown on a monitor.
  • Gloved hand holding a petri dish with orange bacterial colonies streaked across the agar.
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Trusted by leading organisations

Showing slide 1 of 1
Oxford Biotrans

Our project with CPI was the springboard for our technology commercialisation programme and subsequent market launch. The CPI team were knowledgeable, approachable and responsive and proved invaluable in rapidly overcoming the complex challenges that developing any new process requires.

A headshot of Jason King. .

Jason King

CEO

Touchlight Genetics

CPI has skillsets and equipment that are not readily available anywhere else. By using CPI’s skills, we have saved many months of process development.

Headshot of Dr Jill Makin, CTO

Dr Jill Makin

CTO

Calysta

We chose Teesside as a preferred location due to the commercial attractiveness, technical skills and research and development expertise in the area.

Headshot of Alan Shaw, CEO

Alan Shaw

CEO

Trusted by leading organisations

Showing slide 1 of 1
Oxford Biotrans

Our project with CPI was the springboard for our technology commercialisation programme and subsequent market launch. The CPI team were knowledgeable, approachable and responsive and proved invaluable in rapidly overcoming the complex challenges that developing any new process requires.

A headshot of Jason King. .

Jason King

CEO

Touchlight Genetics

CPI has skillsets and equipment that are not readily available anywhere else. By using CPI’s skills, we have saved many months of process development.

Headshot of Dr Jill Makin, CTO

Dr Jill Makin

CTO

Calysta

We chose Teesside as a preferred location due to the commercial attractiveness, technical skills and research and development expertise in the area.

Headshot of Alan Shaw, CEO

Alan Shaw

CEO

Trusted by leading organisations

Showing slide 1 of 1
Oxford Biotrans

Our project with CPI was the springboard for our technology commercialisation programme and subsequent market launch. The CPI team were knowledgeable, approachable and responsive and proved invaluable in rapidly overcoming the complex challenges that developing any new process requires.

A headshot of Jason King. .

Jason King

CEO

Touchlight Genetics

CPI has skillsets and equipment that are not readily available anywhere else. By using CPI’s skills, we have saved many months of process development.

Headshot of Dr Jill Makin, CTO

Dr Jill Makin

CTO

Calysta

We chose Teesside as a preferred location due to the commercial attractiveness, technical skills and research and development expertise in the area.

Headshot of Alan Shaw, CEO

Alan Shaw

CEO

Why choose CPI?

Work with us to defer capital and workforce investments until your product or process is proven at scale.

Dedicated biocatalysis experts

A multidisciplinary team with deep experience in enzymatic process design.

Flexible infrastructure

Scalable systems and high-throughput platforms to speed up development.

Cross-functional integration

Enzyme, reaction, formulation and downstream processing all under one roof.

IP-safe environment

Transparent and secure data practices to protect your innovation.

Regulatory expertise

Support with compliance, certification and data generation for global markets.

Innovation ecosystem

Strong connections across industry, academia, and funding bodies to drive collaboration.

Why choose CPI?

Work with us to defer capital and workforce investments until your product or process is proven at scale.

Dedicated biocatalysis experts

A multidisciplinary team with deep experience in enzymatic process design.

Flexible infrastructure

Scalable systems and high-throughput platforms to speed up development.

Cross-functional integration

Enzyme, reaction, formulation and downstream processing all under one roof.

IP-safe environment

Transparent and secure data practices to protect your innovation.

Regulatory expertise

Support with compliance, certification and data generation for global markets.

Innovation ecosystem

Strong connections across industry, academia, and funding bodies to drive collaboration.

Why choose CPI?

Work with us to defer capital and workforce investments until your product or process is proven at scale.

Dedicated biocatalysis experts

A multidisciplinary team with deep experience in enzymatic process design.

Flexible infrastructure

Scalable systems and high-throughput platforms to speed up development.

Cross-functional integration

Enzyme, reaction, formulation and downstream processing all under one roof.

IP-safe environment

Transparent and secure data practices to protect your innovation.

Regulatory expertise

Support with compliance, certification and data generation for global markets.

Innovation ecosystem

Strong connections across industry, academia, and funding bodies to drive collaboration.

Get in touch

Get in touch

Get in touch

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