Next Generation Biopharmaceutical Downstream Process

Event Details

Start Date
Tue, 04 Sept 2018 09:00
End Date
Tue, 04 Sept 2018 17:00
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Merck is hosting the Next Generation Biopharmaceutical Downstream Process Symposium at CPI, Darlington.

Join us to learn more about the project objectives:

• Implement a fully integrated manufacturing platform based on continuous chromatography 

• Learn single-use disposable techniques for all unit operations of DSP sequence for mAbs at pilot or small production scale 

• Incorporate advanced analytical tools into your process 

Presentation Topics

• Primary separation: substitution of the standard process for primary separation with the utilization of flocculants and Tangential Flow Filtration (TFF).

• Continuous capture step: integration of continuous chromatography in the capture step and development of novel disposable equipment for larger scale. Additionally non-chromatographic capture step alternatives, such as continuous precipitation. 

• Disposable DSP: evaluation of single-use disposable solutions for flow-through polishing steps for efficient removal of impurities and single pass TFF (SPTFF) as continuous product concentration approach. 

• Advanced analytical tools: different tools for measuring impurities, product content and other parameters in real time or close to real time.

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