Principal Scientist – Microbial Upstream

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Job Details

Darlington, England
£48,000 - £64,000 per annum - dependent on experience
Full-time - Permanent
Science and Engineering
28 Jul 2024 - 23:45
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About CPI

CPI helps make great ideas and inventions a reality. We’re a team of intelligent people using advances in science and technology to solve the biggest global challenges in healthcare and sustainability.

Through our incredible people and innovation infrastructure, we collaborate with our partners in industry, academia, government, and the investment community to accelerate the development and commercialisation of innovative products.

From health technologies and pharmaceuticals to sustainable food and materials innovations, we turn the entrepreneurial spirit and radical thinking of our people and partners into incredible impact that makes our world a better place.

Why this role is important for CPI’s work

CPI has an exciting opportunity for an experienced Principal Scientist to join the established and growing microbial upstream team within the biologics technology team based in the National Biologics Manufacturing Centre, Darlington. The Principal Scientist will provide high-level technical expertise and leadership in order to deliver large scale / complex projects and develop technology team level knowledge and practice.

The Principal Scientist acts as a credible technical expert for the organisation, drawing upon a broad range of technical know-how to provide technical expertise and advice to a range of stakeholders, in order to inform technical strategy and direction. Applicants are welcomed from those with significant industry or academic experience within bioprocess development of microbiological and fermentation-based processes. 

The individual we are seeking would play a leading role in the delivery of a breadth of projects within the microbial upstream team. The role will offer opportunities to work across a range of conventional and novel product types including recombinant proteins, virus-like particles and microbiome based therapeutics such as live biotherapeutic products & bacteriophage. 

Working with both aerobic and anaerobic expression systems, the individual will be a key stakeholder both internally and externally to manage the delivery of large projects which encompasses the process design, development and scale-up of fermentation processes towards manufacture and pre-clinical & clinical supply.

Some exciting projects the team have recently worked on are:

  • CPI supported BoobyBiome in the process development of their novel live biotheraputic product.
  • CPI demonstrated the use of cell free expression as an alternative mode of manufacture for recombinant protein production as part of an IUK funded consortia.
  • CPI worked with the University of Leeds to optimise their production process for the supply of their Virus-like-particle therapeutic for Polio treatment.

Key tasks in the role will include (but are not limited to the below), please download the job description for full details available on the CPI careers page:

  • Application of your broad scientific knowledge to projects and client programs. 
  • To identify new technical developments and trends, translating these into building blocks for opportunities across and outside of CPI and initiate the creation of (new) technological innovations/​applications.
  • To utilise own expert knowledge to inform the technology strategy at technology team level, translating this into practice through the creation of deliverable plans to achieve technology team objectives.
  • To build, influence and exploit a network of relevant (inter)national external stakeholders, customers, partners, research organisations and authorities, to represent CPI as the technical expert in networks and discuss and lobby for projects and future developments.
  • To work collaboratively with Business Development and technical colleagues, providing support relating to proposal / project development and direct customer engagement. Seek out and engage in business development opportunities where appropriate. 
  • To formulate and present solutions to a range of stakeholders, using deep technical knowledge to provide up to date views, opinions, and advice to managers, and is regularly sought out to do so. 
  • To set up, plan and execute experimental / pilot scale runs and analyse, interpret, and report the results of these, translating obtained findings and knowledge.
  • To be responsible for providing clearly documented records of technical data, decisions, methodologies, calculations, and software use in an agreed format.

The person we are seeking

Successful candidates will be educated to HNC / Foundation / Degree / Master’s Degree / PhD level (or equivalent) in a Scientific / Engineering discipline plus significant industrial experience at an expert / senior level and;

  • Have experience of leading large cross-function technical development projects.
  • Will possess significant, technical expertise in biologics & bioprocessing, upstream and/​or downstream processing, and/​or analytical characterisation as well as compelling evidence of complex technical problem solving.
  • Will be a recognised industry expert in their area of expertise, as well as having broader technical knowledge and capability, and ability to apply in a variety of contexts.
  • Have significant, practical experience of different expression systems for therapeutic biologics. 
  • Will be familiar with the use of and design of experiment methodologies to inform experimental design. 
  • Will be comfortable using own judgement and initiative within standard engineering / scientific practices, as well as an understanding of when to seek advice from colleagues.
  • Can demonstrate evidence of building knowledge sharing and network building practice across teams. 
  • Actively demonstrates in-depth technical and theoretical knowledge in at least one area and is viewed as a specialist in this area by peers. 

Applications are also particularly welcome from candidates who have chartered status with a relevant professional institution and are an active member of a professional body, engaging with peers beyond CPI.

What does CPI offer you?

At CPI, we offer a wide range of benefits to our employees, this includes:

  • Up to 36 days holiday, including bank holidays – Plus a holiday purchasing scheme
  • Generous pension scheme
  • Life assurance and accident insurance schemes
  • Flexible working
  • Learning and Development Opportunities
  • Free parking

Find out more about our culture and benefits.

Additional information

CPI is an organisation based in the UK. Commencement of employment is conditional to demonstrating right to work in the UK, sponsorship may be available.

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