Scientist — Downstream x2Apply Now
CPI helps make great ideas and inventions a reality. We’re a team of intelligent people using advances in science and technology to solve the biggest global challenges in healthcare and sustainability.
Through our incredible people and innovation infrastructure, we collaborate with our partners in industry, academia, government, and the investment community to accelerate the development and commercialisation of innovative products.
From health technologies and pharmaceuticals to sustainable food and materials innovations, we turn the entrepreneurial spirit and radical thinking of our people and partners into incredible impact that makes our world a better place.
Why this role is important for CPI’s work
CPI has an opportunity for two experienced Scientists to join the established Downstream team. We are looking for enthusiastic and experienced life scientists with a firm understanding of downstream processing of biopharmaceuticals, which can be applied to current and future projects in the fast-moving, collaborative workspace at CPI.
The role will be based at the Biologics business unit in Darlington, where the work supports clients and partners in developing expression systems and processes for their products, including downstream process development using high-throughput screening technology and process scale up for proof-of-concept studies and material supply. With an ever-expanding portfolio of projects in delivery and in the pipeline, which span across a breadth of expression systems, product types and customers, it is a great opportunity to be a part of the future development of the Downstream team.
CPI’s Biologics technical group works on a varied portfolio of projects, working with a wide range of products including monoclonal antibodies, viral vectors, recombinant proteins, microbial therapeutics and synthetically produced nucleic acids using conventional and advanced manufacturing approaches. The work of the group is diverse, examples including:
- Supporting scale of mRNA manufacturing processes with the Vaccine’s taskforce (VTF)
- Developing a manufacturing process for a vaccine-like particle vaccine product
- Development of advanced process control to accelerate drug manufacture[ZA2]
To have and continuously develop a good knowledge/expertise relevant to downstream processing of biopharmaceuticals such as proteins, viral vectors, and nucleic-acid based products expressed in mammalian, bacterial, insect, yeast cells and/or cell-free systems. Your knowledge/expertise should be both practical and theoretical in areas such as:
- Theoretical and practical knowledge in Biochemistry, Biologics Purification, Biochemical Engineering and relevant analytical techniques.
- Lead and deliver experimentation to develop and optimise recovery and purification processes for the manufacture of traditional and novel biopharmaceutical products.
- Application of techniques for the analysis of proteins and other biologics.
- Application of experimental design and statistical concepts to experimental planning.
- Use and application of computer systems and software for data acquisition and analysis.
- Document writing, data interpretation, presentation and statistical analysis.
- Application of your broad scientific knowledge to projects and client programs.
- Knowledge of bioprocessing industry and cGMP concepts.
The person we are seeking
Will be educated to a minimum of HNC or Foundation Degree level (or equivalent) in a Scientific/Engineering discipline plus hold relevant industrial experience at a senior level or educated to Degree level (or equivalent) in a Scientific/Engineering discipline plus hold significant industrial experience.
It is essential that candidates have the ability to demonstrate professional mastery of principles and practices of purification sciences, gained in academic or industrial environments.
Candidates should have wide experience of performing techniques for the purification of therapeutic biologics (for example centrifugation, filtration and chromatography) and associated analysis (for example HPLC/UPLC methods, SDS PAGE & ELISA technologies).
It would be desirable for candidates to have an understanding of GMP principles for the production of biopharmaceuticals.
What does CPI offer you?
At CPI, we offer a wide range of benefits to our employees, this includes:
- Up to 36 days holiday, including bank holidays – Plus a holiday purchasing scheme
- Generous pension scheme
- Life assurance and accident insurance schemes
- Flexible working
- Learning and Development Opportunities
- Free parking
Find out more about our culture and benefits.
CPI is an organisation based in the UK. Commencement of employment is conditional to demonstrating right to work in the UK, sponsorship may be available.