Scientist – Upstream — Mammalian Cell Culture

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Job Details

Darlington, England
£23,000 - £38,000 per annum- dependent on experience
Full-time - Permanent
Science and Engineering
21 Aug 2022 - 11:45
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About CPI

CPI helps make great ideas and inventions a reality. We’re a team of intelligent people using advances in science and technology to solve the biggest global challenges in healthcare and sustainability.

Through our incredible people and innovation infrastructure, we collaborate with our partners in industry, academia, government, and the investment community to accelerate the development and commercialisation of innovative products.

From health technologies and pharmaceuticals to sustainable food and materials innovations, we turn the entrepreneurial spirit and radical thinking of our people and partners into incredible impact that makes our world a better place.

Why this role is important for CPI’s work

CPI is recruiting for an Upstream Scientist to join the established and growing Upstream team, based at the Nigel Perry Building in Darlington. The team of high-performing Scientists are part of CPI’s Biologics business unit. The team plays a key role in delivering a wide range of exciting biologic projects including viral vectors, mAbs, RNA therapeutics, and cellular agriculture.

In your role as an Upstream Scientist, you will use your experience and interest in upstream processing to support the delivery of innovative projects using different cell types (e.g. CHO, HEK293, MDCK, MSCs, and IPSC) to produce biological products such as recombinant proteins, antibodies, exosomes, and viral vectors. The role will involve developing, optimising, and scaling up cell culture processes using suspension, adherent, and/​or continuous cultures. As well as biological therapeutics, CPI is also involved in the development of cellular meat products, owing to its expertise and state of the art facilities to develop the technology and accelerate its path to market. You will be part of a team that generates innovative solutions to problems and will work in a dynamic and fast-moving environment across a wide range of projects.

The Upstream Scientist we are recruiting will quickly adapt to the different aspects of the role and enjoy working in a dynamic and collaborative environment on a range of projects. Pre-existing cell culture experience and experience in solving technical challenges and leveraging input from senior colleagues are essential to be successful in this role. Candidates will be committed to and will actively seek opportunities to develop themselves within this new and exciting role.

Please click on the below links to view some of the teams’ recent successes:

Cobra Biologics

3D Bio-Tissues

Continuous biologics processing


To keep up to date with developments in areas relevant to the role, and/​or legislative and SHE-related changes as communicated by senior colleagues, ensuring understanding of these and any associated new best practices, methods or techniques.

To set up, plan and execute experimental / pilot scale runs and analyse, interpret and report the results of these within agreed timescales and standards and in accordance with project requirements. 

To present and formally report experimental conclusions and supporting data for internal peer review and submission to clients, to agreed timescales and standards. 

To be responsible for providing clearly documented records of technical data, decisions, methodologies, calculations, and software used in an agreed format. 

To take ownership in agreeing weekly work plans with the line manager, project manager(s), and other relevant stakeholders, and delivering a plan to the agreed schedule. 

The person we are seeking

You are required to be educated to a minimum of HNC or Foundation degree (or equivalent) level in a Scientific or Engineering discipline – ideally biology, biochemistry or biological sciences, or related field, with relevant industrial experience. It is desirable that candidates are educated to a degree level (or equivalent) in one of these subjects.

It is essential that you are able to demonstrate knowledge of principles and practices of upstream science and have significant experience in handling cell cultures gained in academic or industrial environments.

You will have expertise in operating cell culture-associated equipment such as bioreactors, centrifuges, cell counters, and other analytical equipment. 

You will have the ability to apply theoretical and practical scientific/​engineering methods to contribute to business activities. 


Experience of upstream process optimisation from bench to pilot scale. 

Familiarity with the use of the design of experimental methodologies to inform experimental design.

Use of high throughput bioreactor platforms. 

Experience with stem cell culture and/​or microcarrier culture.

What does CPI offer you?

At CPI, we offer a wide range of benefits to our employees, this includes:

  • Up to 36 days holiday, including bank holidays – Plus a holiday purchasing scheme
  • Generous pension scheme
  • Life assurance and accident insurance schemes
  • Flexible working
  • Learning and Development Opportunities
  • Free parking

Find out more about our culture and benefits.

Additional information

CPI is an organisation based in the UK. Commencement of employment is conditional to demonstrating right to work in the UK, sponsorship may be available.

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